| Starters | ||
| Pos | Player | Points |
| Total | 0 | |
| Starters | ||
| Pos | Player | Points |
| QB | Jimmy Garoppolo QB | 10.40 |
| RB | Marlon Mack RB | 17.10 |
| RB | Kareem Hunt RB | 6.10 |
| WR | Tyler Lockett WR | 1.70 |
| WR | Michael Thomas WR | 25.60 |
| TE | Darren Waller TE | 5.70 |
| FLEX | DeVante Parker WR | 19.60 |
| FLEX | Raheem Mostert RB | 11.30 |
| DST | Indianapolis Colts DST | 18.00 |
| Total | 115.5 | |
| Bench | ||
| Pos | Player | Points |
| BN | Pittsburgh Steelers DST | 5.00 |
| BN | T.Y. Hilton WR | 4.10 |
| BN | Jack Doyle TE | 2.70 |
| BN | David Johnson RB | 1.20 |
| BN | Davante Adams WR | 16.10 |
| BN | Jameis Winston QB | 11.00 |
| BN | Jamison Crowder WR | 8.00 |
| BN | Seattle Seahawks DST | 2.00 |
| BN | Aaron Rodgers QB | 8.30 |
| BN | Zach Ertz TE | 4.80 |
| BN | Robby Anderson WR | 10.20 |
| BN | James Conner RB | 3.20 |
| BN | Aaron Jones RB | 27.00 |
| BN | Christian McCaffrey RB | 24.80 |
| BN | Breshad Perriman WR | 13.70 |
| BN | Josh Allen QB | 20.60 |
| BN | Phillip Lindsay RB | 18.80 |
| BN | Benny Snell Jr. RB | 1.40 |
| Bench | ||
| Pos | Player | Points |
| BN | Sammy Watkins WR | 3.80 |
| BN | Duke Johnson RB | 0.10 |
| BN | Jacoby Brissett QB | 15.20 |
| BN | Corey Davis WR | 5.50 |
| BN | Tennessee Titans DST | -1.00 |
| BN | Nyheim Hines RB | 1.10 |
| BN | Chris Herndon IV TE | |
| BN | Noah Fant TE | 2.00 |
| BN | Damien Harris RB | |
| BN | Preston Williams WR | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Josh Allen QB | 20.60 | 0% |
| RB | Aaron Jones RB | 27.00 | 0% |
| RB | Christian McCaffrey RB | 24.80 | |
| WR | Davante Adams WR | 16.10 | 0% |
| WR | Breshad Perriman WR | 13.70 | |
| TE | Zach Ertz TE | 4.80 | 0% |
| FLEX | Phillip Lindsay RB | 18.80 | 0% |
| FLEX | Robby Anderson WR | 10.20 | |
| DST | Pittsburgh Steelers DST | 5.00 | 0% |
| Total | 141 | 0% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jacoby Brissett QB | 15.20 | 68.4% |
| RB | Marlon Mack RB | 17.10 | 81.7% |
| RB | Raheem Mostert RB | 11.30 | |
| WR | Michael Thomas WR | 25.60 | 60.4% |
| WR | DeVante Parker WR | 19.60 | |
| TE | Darren Waller TE | 5.70 | 100% |
| FLEX | Kareem Hunt RB | 6.10 | 266.4% |
| FLEX | Corey Davis WR | 5.50 | |
| DST | Indianapolis Colts DST | 18.00 | 100% |
| Total | 124.1 | 93.1% | |