| Starters | ||
| Pos | Player | Points |
| QB | Cam Newton QB | 20.70 |
| RB | Todd Gurley RB | 12.50 |
| RB | Mike Gillislee RB | 2.40 |
| WR | Keenan Allen WR | 7.00 |
| WR | Davante Adams WR | 13.90 |
| TE | Hunter Henry TE | 11.50 |
| FLEX | Jalen Richard RB | 6.50 |
| FLEX | Nelson Agholor WR | 13.50 |
| DST | New York Giants DST | 18.00 |
| Total | 106 | |
| Starters | ||
| Pos | Player | Points |
| QB | Carson Palmer QB | 20.90 |
| RB | Latavius Murray RB | 4.30 |
| RB | Jerick McKinnon RB | 22.40 |
| WR | Kelvin Benjamin WR | 14.40 |
| WR | Pierre Garcon WR | 8.00 |
| TE | Evan Engram TE | 16.70 |
| FLEX | Chris Hogan WR | 2.40 |
| FLEX | Tyrell Williams WR | 2.20 |
| DST | Arizona Cardinals DST | 3.00 |
| Total | 94.3 | |
| Bench | ||
| Pos | Player | Points |
| BN | Sam Bradford QB | 0.00 |
| BN | Jeremy Hill RB | 0.00 |
| BN | C.J. Prosise RB | 0.00 |
| BN | Orleans Darkwa RB | 13.50 |
| BN | Cooper Kupp WR | 4.50 |
| BN | Stefon Diggs WR | 0.00 |
| BN | Chris Conley WR | 0.00 |
| BN | Josh Doctson WR | 7.60 |
| BN | Jared Cook TE | 2.40 |
| BN | Gerald Everett TE | 6.90 |
| Bench | ||
| Pos | Player | Points |
| BN | Marcus Mariota QB | 14.20 |
| BN | Trevor Siemian QB | 15.90 |
| BN | Dion Lewis RB | 12.00 |
| BN | J.J. Nelson WR | 1.60 |
| BN | Pittsburgh Steelers DST | 10.00 |
| BN | Charcandrick West RB | 1.40 |
| BN | Kerwynn Williams RB | 2.80 |
| BN | Chris Johnson RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Cam Newton QB | 20.70 | 100% |
| RB | Orleans Darkwa RB | 13.50 | 57.3% |
| RB | Todd Gurley RB | 12.50 | |
| WR | Davante Adams WR | 13.90 | 76.3% |
| WR | Nelson Agholor WR | 13.50 | |
| TE | Hunter Henry TE | 11.50 | 100% |
| FLEX | Josh Doctson WR | 7.60 | 137% |
| FLEX | Keenan Allen WR | 7.00 | |
| DST | New York Giants DST | 18.00 | 100% |
| Total | 118.2 | 89.7% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Carson Palmer QB | 20.90 | 100% |
| RB | Jerick McKinnon RB | 22.40 | 77.6% |
| RB | Dion Lewis RB | 12.00 | |
| WR | Kelvin Benjamin WR | 14.40 | 100% |
| WR | Pierre Garcon WR | 8.00 | |
| TE | Evan Engram TE | 16.70 | 100% |
| FLEX | Latavius Murray RB | 4.30 | 64.8% |
| FLEX | Kerwynn Williams RB | 2.80 | |
| DST | Pittsburgh Steelers DST | 10.00 | 30% |
| Total | 111.5 | 84.6% | |