| Starters | ||
| Pos | Player | Points |
| QB | Jacoby Brissett QB | 14.00 |
| RB | LeVeon Bell RB | 26.60 |
| RB | Devonta Freeman RB | 8.90 |
| WR | Tyreek Hill WR | 7.00 |
| WR | Adam Thielen WR | 14.10 |
| TE | Zach Miller TE | 9.50 |
| FLEX | Lamar Miller RB | 9.60 |
| FLEX | Danny Amendola WR | 6.50 |
| DST | New England Patriots DST | 6.00 |
| Total | 102.2 | |
| Starters | ||
| Pos | Player | Points |
| QB | Alex Smith QB | 15.10 |
| RB | Ty Montgomery RB | 3.60 |
| RB | Marshawn Lynch RB | 6.30 |
| WR | DeSean Jackson WR | 11.30 |
| WR | Golden Tate WR | 19.10 |
| TE | George Kittle TE | 6.60 |
| FLEX | Julio Jones WR | 10.20 |
| FLEX | Jarvis Landry WR | 16.20 |
| DST | Kansas City Chiefs DST | 1.00 |
| Total | 89.4 | |
| Bench | ||
| Pos | Player | Points |
| BN | Andrew Luck QB | 0.00 |
| BN | Jamaal Charles RB | 2.60 |
| BN | Joe Flacco QB | 5.40 |
| BN | Ted Ginn Jr. WR | 16.50 |
| BN | Martellus Bennett TE | 3.20 |
| BN | Cincinnati Bengals DST | 0.00 |
| BN | Austin Hooper TE | 8.30 |
| BN | Geronimo Allison WR | 1.20 |
| BN | Mack Hollins WR | 4.80 |
| BN | Kenny Stills WR | 12.90 |
| Bench | ||
| Pos | Player | Points |
| BN | Detroit Lions DST | 16.00 |
| BN | Taylor Gabriel WR | 5.90 |
| BN | Kirk Cousins QB | 27.80 |
| BN | LeGarrette Blount RB | 8.70 |
| BN | Frank Gore RB | 7.70 |
| BN | Bilal Powell RB | 0.00 |
| BN | Kenny Britt WR | 0.00 |
| BN | Jimmy Graham TE | 0.00 |
| BN | Shane Vereen RB | 0.40 |
| BN | Samaje Perine RB | 12.20 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jacoby Brissett QB | 14.00 | 100% |
| RB | LeVeon Bell RB | 26.60 | 98.1% |
| RB | Lamar Miller RB | 9.60 | |
| WR | Ted Ginn Jr. WR | 16.50 | 69% |
| WR | Adam Thielen WR | 14.10 | |
| TE | Zach Miller TE | 9.50 | 100% |
| FLEX | Kenny Stills WR | 12.90 | 73.9% |
| FLEX | Devonta Freeman RB | 8.90 | |
| DST | New England Patriots DST | 6.00 | 100% |
| Total | 118.1 | 86.5% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kirk Cousins QB | 27.80 | 54.3% |
| RB | Samaje Perine RB | 12.20 | 47.4% |
| RB | LeGarrette Blount RB | 8.70 | |
| WR | Golden Tate WR | 19.10 | 86.1% |
| WR | Jarvis Landry WR | 16.20 | |
| TE | George Kittle TE | 6.60 | 100% |
| FLEX | DeSean Jackson WR | 11.30 | 122.8% |
| FLEX | Julio Jones WR | 10.20 | |
| DST | Detroit Lions DST | 16.00 | 6.3% |
| Total | 128.1 | 69.8% | |