| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 19.10 |
| RB | Mark Ingram RB | 19.00 |
| RB | LeSean McCoy RB | 24.70 |
| WR | Antonio Brown WR | 14.90 |
| WR | Michael Crabtree WR | 9.90 |
| TE | Delanie Walker TE | 7.80 |
| FLEX | Joe Mixon RB | 8.30 |
| FLEX | Jordy Nelson WR | 1.80 |
| DST | Los Angeles Chargers DST | 24.00 |
| Total | 129.5 | |
| Starters | ||
| Pos | Player | Points |
| QB | Ben Roethlisberger QB | 16.70 |
| RB | Christian McCaffrey RB | 9.00 |
| RB | Jay Ajayi RB | 9.20 |
| WR | Brandin Cooks WR | 14.50 |
| WR | Larry Fitzgerald WR | 4.40 |
| TE | Zach Ertz TE | 17.40 |
| FLEX | Chris Thompson RB | 15.80 |
| FLEX | Dez Bryant WR | 15.80 |
| DST | Baltimore Ravens DST | 1.00 |
| Total | 103.8 | |
| Bench | ||
| Pos | Player | Points |
| BN | Wendell Smallwood RB | 4.90 |
| BN | Martavis Bryant WR | 1.00 |
| BN | Robby Anderson WR | 11.00 |
| BN | James Conner RB | 1.90 |
| BN | Deshaun Watson QB | 0.00 |
| BN | Terrelle Pryor WR | 2.40 |
| BN | Benjamin Watson TE | 6.30 |
| BN | New York Jets DST | 5.00 |
| BN | Matt Breida RB | 0.50 |
| BN | Wayne Gallman RB | 3.90 |
| Bench | ||
| Pos | Player | Points |
| BN | Aaron Rodgers QB | 0.00 |
| BN | DeShone Kizer QB | 0.60 |
| BN | DeMarco Murray RB | 9.10 |
| BN | Emmanuel Sanders WR | 0.00 |
| BN | John Brown WR | 1.10 |
| BN | Marvin Jones WR | 0.00 |
| BN | Buffalo Bills DST | 4.00 |
| BN | Jason Witten TE | 13.40 |
| BN | Tennessee Titans DST | 13.00 |
| BN | Aaron Jones RB | 21.30 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Brees QB | 19.10 | 100% |
| RB | LeSean McCoy RB | 24.70 | 100% |
| RB | Mark Ingram RB | 19.00 | |
| WR | Antonio Brown WR | 14.90 | 95.8% |
| WR | Robby Anderson WR | 11.00 | |
| TE | Delanie Walker TE | 7.80 | 100% |
| FLEX | Michael Crabtree WR | 9.90 | 55.5% |
| FLEX | Joe Mixon RB | 8.30 | |
| DST | Los Angeles Chargers DST | 24.00 | 100% |
| Total | 138.7 | 93.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Ben Roethlisberger QB | 16.70 | 100% |
| RB | Aaron Jones RB | 21.30 | 49.1% |
| RB | Chris Thompson RB | 15.80 | |
| WR | Dez Bryant WR | 15.80 | 62.4% |
| WR | Brandin Cooks WR | 14.50 | |
| TE | Zach Ertz TE | 17.40 | 100% |
| FLEX | Jason Witten TE | 13.40 | 139.8% |
| FLEX | Jay Ajayi RB | 9.20 | |
| DST | Tennessee Titans DST | 13.00 | 7.7% |
| Total | 137.1 | 75.7% | |