| Starters | ||
| Pos | Player | Points |
| QB | Joe Burrow QB | 22.86 |
| RB | David Montgomery RB | 11.50 |
| RB | Lamical Perine RB | 4.30 |
| WR | Jarvis Landry WR | 7.20 |
| WR | A.J. Brown WR | 10.40 |
| TE | George Kittle TE | 4.90 |
| FLEX | Mike Williams WR | 18.50 |
| FLEX | Chase Claypool WR | 10.70 |
| DST | Los Angeles Rams DST | 8.00 |
| Total | 98.36 | |
| Starters | ||
| Pos | Player | Points |
| QB | Teddy Bridgewater QB | 12.04 |
| RB | Derrick Henry RB | 17.20 |
| RB | Jamaal Williams RB | 15.20 |
| WR | Julio Jones WR | 17.20 |
| WR | Cole Beasley WR | 3.40 |
| TE | Travis Kelce TE | 20.90 |
| FLEX | Travis Fulgham WR | 16.80 |
| FLEX | Darrell Henderson RB | 6.30 |
| DST | Los Angeles Chargers DST | 2.00 |
| Total | 111.04 | |
| Bench | ||
| Pos | Player | Points |
| BN | Carlos Hyde RB | 0.00 |
| BN | Rex Burkhead RB | 3.60 |
| BN | Frank Gore RB | 3.00 |
| BN | Golden Tate WR | 10.82 |
| BN | San Francisco 49ers DST | -2.00 |
| BN | Chris Godwin WR | 0.00 |
| BN | Irv Smith Jr. TE | 2.10 |
| BN | Robert Tonyan TE | 10.40 |
| BN | Jerry Jeudy WR | 9.30 |
| BN | Van Jefferson WR | 3.30 |
| Bench | ||
| Pos | Player | Points |
| BN | James White RB | 4.50 |
| BN | Emmanuel Sanders WR | 0.00 |
| BN | Green Bay Packers DST | 0.00 |
| BN | Adam Humphries WR | 0.00 |
| BN | Chase Edmonds RB | 0.00 |
| BN | Mike Gesicki TE | 1.30 |
| BN | Dallas Goedert TE | 2.00 |
| BN | Mecole Hardman WR | 19.80 |
| BN | Gardner Minshew QB | 0.00 |
| BN | Cam Akers RB | 5.90 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Joe Burrow QB | 22.86 | 100% |
| RB | David Montgomery RB | 11.50 | 100% |
| RB | Lamical Perine RB | 4.30 | |
| WR | Mike Williams WR | 18.50 | 60% |
| WR | Golden Tate WR | 10.82 | |
| TE | Robert Tonyan TE | 10.40 | 47.1% |
| FLEX | Chase Claypool WR | 10.70 | 138.4% |
| FLEX | A.J. Brown WR | 10.40 | |
| DST | Los Angeles Rams DST | 8.00 | 100% |
| Total | 107.48 | 91.5% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 28.28 | 42.6% |
| RB | Derrick Henry RB | 17.20 | 100% |
| RB | Jamaal Williams RB | 15.20 | |
| WR | Mecole Hardman WR | 19.80 | 55.7% |
| WR | Julio Jones WR | 17.20 | |
| TE | Travis Kelce TE | 20.90 | 100% |
| FLEX | Travis Fulgham WR | 16.80 | 82.2% |
| FLEX | Anthony Miller WR | 11.30 | |
| DST | Los Angeles Chargers DST | 2.00 | 100% |
| Total | 148.68 | 74.7% | |