| Starters | ||
| Pos | Player | Points |
| QB | Patrick Mahomes QB | 46.64 |
| RB | LeVeon Bell RB | 5.30 |
| RB | Devin Singletary RB | 9.70 |
| WR | Tyreek Hill WR | 23.80 |
| WR | Henry Ruggs III WR | 1.90 |
| TE | Jared Cook TE | 13.60 |
| FLEX | Kyle Rudolph TE | 1.70 |
| FLEX | J.K. Dobbins RB | 12.60 |
| DST | Baltimore Ravens DST | 6.00 |
| Total | 121.24 | |
| Starters | ||
| Pos | Player | Points |
| QB | Tom Brady QB | 23.06 |
| RB | Dalvin Cook RB | 47.60 |
| RB | Phillip Lindsay RB | 15.10 |
| WR | Allen Robinson WR | 17.70 |
| WR | Mike Evans WR | 14.00 |
| TE | Hayden Hurst TE | 7.90 |
| FLEX | Marquez Valdes-Scantling WR | 2.80 |
| FLEX | Alexander Mattison RB | 0.80 |
| DST | New England Patriots DST | 3.00 |
| Total | 131.96 | |
| Bench | ||
| Pos | Player | Points |
| BN | Odell Beckham WR | 0.00 |
| BN | LeSean McCoy RB | 0.00 |
| BN | Sammy Watkins WR | 0.00 |
| BN | Chris Thompson RB | 0.00 |
| BN | Joe Flacco QB | 0.00 |
| BN | Houston Texans DST | 0.00 |
| BN | DOnta Foreman RB | 3.70 |
| BN | Kenny Stills WR | 0.00 |
| BN | Justice Hill RB | 0.00 |
| BN | Justin Herbert QB | 23.22 |
| Bench | ||
| Pos | Player | Points |
| BN | Peyton Barber RB | 0.00 |
| BN | Jacksonville Jaguars DST | 0.00 |
| BN | Jordan Howard RB | 0.00 |
| BN | Kenyan Drake RB | 0.00 |
| BN | Dalton Schultz TE | 8.30 |
| BN | Auden Tate WR | 10.00 |
| BN | Kyler Murray QB | 0.00 |
| BN | Drew Lock QB | 23.82 |
| BN | NKeal Harry TE | 0.00 |
| BN | KeShawn Vaughn RB | 0.00 |
| BN | K.J. Hamler WR | 8.80 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Patrick Mahomes QB | 46.64 | 100% |
| RB | J.K. Dobbins RB | 12.60 | 67.3% |
| RB | Devin Singletary RB | 9.70 | |
| WR | Tyreek Hill WR | 23.80 | 100% |
| WR | Henry Ruggs III WR | 1.90 | |
| TE | Jared Cook TE | 13.60 | 100% |
| FLEX | LeVeon Bell RB | 5.30 | 158.9% |
| FLEX | DOnta Foreman RB | 3.70 | |
| DST | Baltimore Ravens DST | 6.00 | 100% |
| Total | 123.24 | 98.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Lock QB | 23.82 | 96.8% |
| RB | Dalvin Cook RB | 47.60 | 100% |
| RB | Phillip Lindsay RB | 15.10 | |
| WR | Allen Robinson WR | 17.70 | 100% |
| WR | Mike Evans WR | 14.00 | |
| TE | Dalton Schultz TE | 8.30 | 95.2% |
| FLEX | Auden Tate WR | 10.00 | 19.1% |
| FLEX | K.J. Hamler WR | 8.80 | |
| DST | New England Patriots DST | 3.00 | 100% |
| Total | 148.32 | 89% | |