| Starters | ||
| Pos | Player | Points |
| QB | Teddy Bridgewater QB | 32.30 |
| RB | Derrick Henry RB | 6.80 |
| RB | Chase Edmonds RB | 10.30 |
| WR | Julio Jones WR | 13.90 |
| WR | Cole Beasley WR | 5.40 |
| TE | Travis Kelce TE | 20.90 |
| FLEX | Emmanuel Sanders WR | 11.80 |
| FLEX | Mecole Hardman WR | 6.60 |
| DST | Green Bay Packers DST | 6.00 |
| Total | 114 | |
| Starters | ||
| Pos | Player | Points |
| QB | Josh Allen QB | 42.00 |
| RB | James Conner RB | 3.00 |
| RB | Christian McCaffrey RB | 32.10 |
| WR | Davante Adams WR | 28.30 |
| WR | Jamison Crowder WR | 9.60 |
| TE | Hunter Henry TE | 5.30 |
| FLEX | David Johnson RB | 1.60 |
| FLEX | Marvin Jones WR | 11.80 |
| DST | Pittsburgh Steelers DST | 5.00 |
| Total | 138.7 | |
| Bench | ||
| Pos | Player | Points |
| BN | James White RB | 4.40 |
| BN | Los Angeles Chargers DST | 2.00 |
| BN | Adam Humphries WR | 0.00 |
| BN | Jamaal Williams RB | 0.00 |
| BN | Mike Gesicki TE | 5.70 |
| BN | Dallas Goedert TE | |
| BN | Travis Fulgham WR | 0.00 |
| BN | Darrell Henderson RB | 0.00 |
| BN | Gardner Minshew QB | 0.00 |
| BN | Cam Akers RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Amari Cooper WR | 10.00 |
| BN | Jack Doyle TE | 0.00 |
| BN | Seattle Seahawks DST | 1.00 |
| BN | Ben Roethlisberger QB | 31.04 |
| BN | Aaron Jones RB | 10.40 |
| BN | Breshad Perriman WR | 24.60 |
| BN | Deonte Harris WR | 6.00 |
| BN | Benny Snell Jr. RB | 0.10 |
| BN | Scott Miller WR | 1.50 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Teddy Bridgewater QB | 32.30 | 100% |
| RB | Chase Edmonds RB | 10.30 | 100% |
| RB | Derrick Henry RB | 6.80 | |
| WR | Julio Jones WR | 13.90 | 75.1% |
| WR | Emmanuel Sanders WR | 11.80 | |
| TE | Travis Kelce TE | 20.90 | 100% |
| FLEX | James Washington WR | 8.20 | 124.3% |
| FLEX | Mecole Hardman WR | 6.60 | |
| DST | Green Bay Packers DST | 6.00 | 100% |
| Total | 116.8 | 97.6% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Josh Allen QB | 42.00 | 100% |
| RB | Christian McCaffrey RB | 32.10 | 82.6% |
| RB | Aaron Jones RB | 10.40 | |
| WR | Davante Adams WR | 28.30 | 71.6% |
| WR | Breshad Perriman WR | 24.60 | |
| TE | Hunter Henry TE | 5.30 | 100% |
| FLEX | Marvin Jones WR | 11.80 | 61.5% |
| FLEX | Amari Cooper WR | 10.00 | |
| DST | Pittsburgh Steelers DST | 5.00 | 100% |
| Total | 169.5 | 81.8% | |