| Starters | ||
| Pos | Player | Points |
| QB | Alex Smith QB | 25.70 |
| RB | Marshawn Lynch RB | 0.90 |
| RB | Samaje Perine RB | 0.00 |
| WR | Taylor Gabriel WR | 2.90 |
| WR | Kenny Britt WR | 1.70 |
| TE | Tyler Kroft TE | 10.30 |
| FLEX | LeGarrette Blount RB | 2.90 |
| FLEX | George Kittle TE | 2.10 |
| DST | Kansas City Chiefs DST | -5.00 |
| Total | 41.5 | |
| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 15.30 |
| RB | Carlos Hyde RB | 10.80 |
| RB | Jordan Howard RB | 6.50 |
| WR | Tyler Lockett WR | 10.40 |
| WR | Willie Snead WR | 0.00 |
| TE | Travis Kelce TE | 11.30 |
| FLEX | Derrick Henry RB | 3.40 |
| FLEX | Cameron Brate TE | 9.00 |
| DST | Los Angeles Rams DST | 15.00 |
| Total | 81.7 | |
| Bench | ||
| Pos | Player | Points |
| BN | Kirk Cousins QB | 23.90 |
| BN | Frank Gore RB | 3.40 |
| BN | Bilal Powell RB | 9.30 |
| BN | Ty Montgomery RB | 2.00 |
| BN | Julio Jones WR | 20.40 |
| BN | Golden Tate WR | 0.00 |
| BN | Jarvis Landry WR | 19.60 |
| BN | DeSean Jackson WR | 9.80 |
| BN | Jimmy Graham TE | 12.60 |
| BN | Detroit Lions DST | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | David Johnson RB | 0.00 |
| BN | Terrance West RB | 0.00 |
| BN | Theo Riddick RB | 0.00 |
| BN | Devontae Booker RB | 4.30 |
| BN | Odell Beckham WR | 0.00 |
| BN | Jordan Matthews TE | 2.00 |
| BN | Donte Moncrief WR | 4.00 |
| BN | Philadelphia Eagles DST | 6.00 |
| BN | DeAngelo Henderson RB | 0.00 |
| BN | Jay Cutler QB | 11.50 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Alex Smith QB | 25.70 | 100% |
| RB | Bilal Powell RB | 9.30 | 7.1% |
| RB | Frank Gore RB | 3.40 | |
| WR | Julio Jones WR | 20.40 | 11.5% |
| WR | Jarvis Landry WR | 19.60 | |
| TE | Jimmy Graham TE | 12.60 | 81.7% |
| FLEX | Tyler Kroft TE | 10.30 | 24.9% |
| FLEX | DeSean Jackson WR | 9.80 | |
| DST | Detroit Lions DST | 0.00 | -- |
| Total | 111.1 | 37.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 15.30 | 100% |
| RB | Carlos Hyde RB | 10.80 | 100% |
| RB | Jordan Howard RB | 6.50 | |
| WR | Tyler Lockett WR | 10.40 | 72.2% |
| WR | Donte Moncrief WR | 4.00 | |
| TE | Travis Kelce TE | 11.30 | 100% |
| FLEX | Cameron Brate TE | 9.00 | 93.2% |
| FLEX | Devontae Booker RB | 4.30 | |
| DST | Los Angeles Rams DST | 15.00 | 100% |
| Total | 86.6 | 94.3% | |