| Starters | ||
| Pos | Player | Points |
| QB | Deshaun Watson QB | 39.12 |
| RB | Giovani Bernard RB | 5.90 |
| RB | Josh Jacobs RB | 3.90 |
| WR | DeAndre Hopkins WR | 8.00 |
| WR | D.K. Metcalf WR | 22.70 |
| TE | T.J. Hockenson TE | 11.40 |
| FLEX | Chris Carson RB | 12.90 |
| FLEX | Diontae Johnson WR | 8.60 |
| DST | Tennessee Titans DST | 12.00 |
| Total | 124.52 | |
| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 19.80 |
| RB | Derrick Henry RB | 37.50 |
| RB | Chase Edmonds RB | 7.20 |
| WR | Cole Beasley WR | 10.30 |
| WR | Jakobi Meyers WR | 7.70 |
| TE | Travis Kelce TE | 12.20 |
| FLEX | James White RB | 14.20 |
| FLEX | Dallas Goedert TE | 17.00 |
| DST | Green Bay Packers DST | 14.00 |
| Total | 139.9 | |
| Bench | ||
| Pos | Player | Points |
| BN | Antonio Brown WR | 2.20 |
| BN | Tampa Bay Buccaneers DST | -2.00 |
| BN | Ronald Jones II RB | 16.80 |
| BN | Kalen Ballage RB | |
| BN | Salvon Ahmed RB | |
| BN | CeeDee Lamb WR | 5.05 |
| BN | Bryan Edwards WR | 2.00 |
| BN | Laviska Shenault Jr. WR | 5.20 |
| BN | Tua Tagovailoa QB | |
| Bench | ||
| Pos | Player | Points |
| BN | Julio Jones WR | |
| BN | Devontae Booker RB | 1.00 |
| BN | Los Angeles Chargers DST | 9.00 |
| BN | Emmanuel Sanders WR | 0.90 |
| BN | Teddy Bridgewater QB | 13.88 |
| BN | Jamaal Williams RB | 13.30 |
| BN | Travis Fulgham WR | 2.60 |
| BN | Mecole Hardman WR | 4.80 |
| BN | Darrell Henderson RB | 1.90 |
| BN | Cam Akers RB | 14.40 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Deshaun Watson QB | 39.12 | 100% |
| RB | Ronald Jones II RB | 16.80 | 33% |
| RB | Chris Carson RB | 12.90 | |
| WR | D.K. Metcalf WR | 22.70 | 98.1% |
| WR | Diontae Johnson WR | 8.60 | |
| TE | Richard Rodgers TE | 12.80 | 89.1% |
| FLEX | T.J. Hockenson TE | 11.40 | 110.8% |
| FLEX | DeAndre Hopkins WR | 8.00 | |
| DST | Tennessee Titans DST | 12.00 | 100% |
| Total | 144.32 | 86.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 19.80 | 100% |
| RB | Derrick Henry RB | 37.50 | 80% |
| RB | Austin Ekeler RB | 18.40 | |
| WR | Allen Lazard WR | 10.30 | 87.4% |
| WR | Cole Beasley WR | 10.30 | |
| TE | Dallas Goedert TE | 17.00 | 71.8% |
| FLEX | Cam Akers RB | 14.40 | 109.1% |
| FLEX | James White RB | 14.20 | |
| DST | Green Bay Packers DST | 14.00 | 100% |
| Total | 155.9 | 89.7% | |