| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 10.50 |
| RB | Carlos Hyde RB | 6.70 |
| RB | Jordan Howard RB | 13.60 |
| WR | Jordan Matthews WR | 3.60 |
| WR | Tyler Lockett WR | 17.00 |
| TE | Travis Kelce TE | 22.80 |
| FLEX | Theo Riddick RB | 5.50 |
| FLEX | Cameron Brate TE | 8.40 |
| DST | Philadelphia Eagles DST | 21.00 |
| Total | 109.1 | |
| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 11.80 |
| RB | Mark Ingram RB | 14.90 |
| RB | LeSean McCoy RB | 26.30 |
| WR | Antonio Brown WR | 9.50 |
| WR | Michael Crabtree WR | 10.80 |
| TE | Nick OLeary TE | 1.00 |
| FLEX | Joe Mixon RB | 10.40 |
| FLEX | Wendell Smallwood RB | 1.90 |
| DST | Miami Dolphins DST | 3.00 |
| Total | 89.6 | |
| Bench | ||
| Pos | Player | Points |
| BN | David Johnson RB | 0.00 |
| BN | Derrick Henry RB | 0.00 |
| BN | Terrance West RB | 0.00 |
| BN | Devontae Booker RB | 12.90 |
| BN | Odell Beckham WR | 0.00 |
| BN | Donte Moncrief WR | 0.00 |
| BN | Willie Snead WR | 0.00 |
| BN | Los Angeles Rams DST | 0.00 |
| BN | DeAngelo Henderson RB | 0.00 |
| BN | Jay Cutler QB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Jordy Nelson WR | 0.00 |
| BN | Martavis Bryant WR | 0.00 |
| BN | Robby Anderson WR | 19.50 |
| BN | Delanie Walker TE | 0.00 |
| BN | James Conner RB | 0.10 |
| BN | Deshaun Watson QB | 32.80 |
| BN | Terrelle Pryor WR | 0.00 |
| BN | Benjamin Watson TE | 7.60 |
| BN | Matt Breida RB | 13.60 |
| BN | Los Angeles Chargers DST | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 10.50 | 100% |
| RB | Jordan Howard RB | 13.60 | 76.6% |
| RB | Devontae Booker RB | 12.90 | |
| WR | Tyler Lockett WR | 17.00 | 121.2% |
| WR | Willie Snead WR | 0.00 | |
| TE | Travis Kelce TE | 22.80 | 100% |
| FLEX | Cameron Brate TE | 8.40 | 92.1% |
| FLEX | Carlos Hyde RB | 6.70 | |
| DST | Philadelphia Eagles DST | 21.00 | 100% |
| Total | 112.9 | 96.6% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Deshaun Watson QB | 32.80 | 36% |
| RB | LeSean McCoy RB | 26.30 | 100% |
| RB | Mark Ingram RB | 14.90 | |
| WR | Robby Anderson WR | 19.50 | 67% |
| WR | Michael Crabtree WR | 10.80 | |
| TE | Benjamin Watson TE | 7.60 | 13.2% |
| FLEX | Matt Breida RB | 13.60 | 51.3% |
| FLEX | Joe Mixon RB | 10.40 | |
| DST | Miami Dolphins DST | 3.00 | 100% |
| Total | 138.9 | 64.5% | |