| Starters | ||
| Pos | Player | Points |
| QB | Russell Wilson QB | 9.08 |
| RB | Latavius Murray RB | 4.00 |
| RB | Jonathan Taylor RB | 30.40 |
| WR | Robert Woods WR | 21.00 |
| WR | Justin Jefferson WR | 15.90 |
| TE | Hunter Henry TE | 16.50 |
| FLEX | Zack Moss RB | 10.70 |
| FLEX | DeVonta Smith WR | 11.20 |
| DST | New Orleans Saints DST | 5.00 |
| Total | 123.78 | |
| Starters | ||
| Pos | Player | Points |
| QB | Matthew Stafford QB | 16.50 |
| RB | Miles Sanders RB | 7.60 |
| RB | Antonio Gibson RB | 20.20 |
| WR | Stefon Diggs WR | 7.90 |
| WR | Cooper Kupp WR | 13.30 |
| TE | Mark Andrews TE | 36.20 |
| FLEX | Jakobi Meyers WR | 7.60 |
| FLEX | Deebo Samuel WR | 14.60 |
| DST | Cleveland Browns DST | -6.00 |
| Total | 117.9 | |
| Bench | ||
| Pos | Player | Points |
| BN | Will Fuller WR | 0.00 |
| BN | Tevin Coleman RB | 5.70 |
| BN | Kenyan Drake RB | 2.85 |
| BN | San Francisco 49ers DST | 5.00 |
| BN | Baker Mayfield QB | 27.00 |
| BN | Cole Kmet TE | 3.20 |
| BN | Pat Freiermuth TE | 1.70 |
| BN | Justin Fields QB | 10.84 |
| Bench | ||
| Pos | Player | Points |
| BN | Josh Gordon WR | 1.60 |
| BN | Jameis Winston QB | 31.76 |
| BN | Indianapolis Colts DST | -3.00 |
| BN | Nyheim Hines RB | 3.30 |
| BN | Calvin Ridley WR | 0.00 |
| BN | Jalen Hurts QB | 20.92 |
| BN | Rhamondre Stevenson RB | 2.30 |
| BN | Kenneth Gainwell RB | 2.90 |
| BN | Larry Rountree RB | 2.25 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Baker Mayfield QB | 27.00 | 33.6% |
| RB | Jonathan Taylor RB | 30.40 | 83.7% |
| RB | Zack Moss RB | 10.70 | |
| WR | Robert Woods WR | 21.00 | 100% |
| WR | Justin Jefferson WR | 15.90 | |
| TE | Hunter Henry TE | 16.50 | 100% |
| FLEX | DeVonta Smith WR | 11.20 | 129.6% |
| FLEX | Tevin Coleman RB | 5.70 | |
| DST | San Francisco 49ers DST | 5.00 | 100% |
| Total | 143.4 | 86.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jameis Winston QB | 31.76 | 52% |
| RB | Antonio Gibson RB | 20.20 | 100% |
| RB | Miles Sanders RB | 7.60 | |
| WR | Deebo Samuel WR | 14.60 | 76% |
| WR | Cooper Kupp WR | 13.30 | |
| TE | Mark Andrews TE | 36.20 | 100% |
| FLEX | Donovan Peoples-Jones WR | 9.50 | 127.6% |
| FLEX | Stefon Diggs WR | 7.90 | |
| DST | Indianapolis Colts DST | -3.00 | -- |
| Total | 138.06 | 85.4% | |