| Starters | ||
| Pos | Player | Points |
| QB | Josh McCown QB | 18.30 |
| RB | Dion Lewis RB | 11.20 |
| RB | Jerick McKinnon RB | 23.20 |
| WR | Kelvin Benjamin WR | 11.40 |
| WR | Pierre Garcon WR | 2.70 |
| TE | Ed Dickson TE | 4.40 |
| FLEX | Latavius Murray RB | 5.20 |
| FLEX | Chris Hogan WR | 8.50 |
| DST | Pittsburgh Steelers DST | 0.00 |
| Total | 84.9 | |
| Starters | ||
| Pos | Player | Points |
| QB | Alex Smith QB | 13.40 |
| RB | Samaje Perine RB | 0.00 |
| RB | Frank Gore RB | 12.10 |
| WR | Jarvis Landry WR | 6.00 |
| WR | DeSean Jackson WR | 5.20 |
| TE | Tyler Kroft TE | 7.10 |
| FLEX | LeGarrette Blount RB | 11.70 |
| FLEX | George Kittle TE | 3.20 |
| DST | Detroit Lions DST | 3.00 |
| Total | 61.7 | |
| Bench | ||
| Pos | Player | Points |
| BN | Marcus Mariota QB | 0.00 |
| BN | Carson Palmer QB | 0.00 |
| BN | Trevor Siemian QB | 7.90 |
| BN | Arizona Cardinals DST | 0.00 |
| BN | Charcandrick West RB | 0.90 |
| BN | Tyrell Williams WR | 2.90 |
| BN | Kerwynn Williams RB | 0.00 |
| BN | Evan Engram TE | 0.00 |
| BN | Randall Cobb WR | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Kirk Cousins QB | 10.50 |
| BN | Marshawn Lynch RB | 0.00 |
| BN | Bilal Powell RB | 7.60 |
| BN | Ty Montgomery RB | 0.00 |
| BN | Golden Tate WR | 10.10 |
| BN | Taylor Gabriel WR | 0.20 |
| BN | Kansas City Chiefs DST | 18.00 |
| BN | DeVante Parker WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Josh McCown QB | 18.30 | 100% |
| RB | Jerick McKinnon RB | 23.20 | 100% |
| RB | Dion Lewis RB | 11.20 | |
| WR | Kelvin Benjamin WR | 11.40 | 70.9% |
| WR | Chris Hogan WR | 8.50 | |
| TE | Ed Dickson TE | 4.40 | 100% |
| FLEX | Latavius Murray RB | 5.20 | 169.1% |
| FLEX | Tyrell Williams WR | 2.90 | |
| DST | Arizona Cardinals DST | 0.00 | -- |
| Total | 85.1 | 99.8% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Alex Smith QB | 13.40 | 100% |
| RB | Frank Gore RB | 12.10 | 50.8% |
| RB | LeGarrette Blount RB | 11.70 | |
| WR | Golden Tate WR | 10.10 | 69.6% |
| WR | Jarvis Landry WR | 6.00 | |
| TE | Tyler Kroft TE | 7.10 | 100% |
| FLEX | Bilal Powell RB | 7.60 | 116.4% |
| FLEX | DeSean Jackson WR | 5.20 | |
| DST | Kansas City Chiefs DST | 18.00 | 16.7% |
| Total | 91.2 | 67.7% | |