| Starters | ||
| Pos | Player | Points |
| QB | Sam Darnold QB | 11.76 |
| RB | Darrel Williams RB | 14.00 |
| RB | Chuba Hubbard RB | 13.60 |
| WR | Tee Higgins WR | 11.70 |
| WR | Michael Pittman Jr. WR | 25.60 |
| TE | Tyler Higbee TE | 4.00 |
| FLEX | Adam Thielen WR | 16.80 |
| FLEX | Tony Pollard RB | 4.30 |
| DST | Buffalo Bills DST | 11.00 |
| Total | 112.76 | |
| Starters | ||
| Pos | Player | Points |
| QB | Matt Ryan QB | 4.14 |
| RB | Joe Mixon RB | 23.10 |
| RB | Cordarrelle Patterson RB | 16.95 |
| WR | DeAndre Hopkins WR | 7.60 |
| WR | D.K. Metcalf WR | 19.30 |
| TE | T.J. Hockenson TE | 13.90 |
| FLEX | Diontae Johnson WR | 12.80 |
| FLEX | CeeDee Lamb WR | 14.05 |
| DST | Tampa Bay Buccaneers DST | -1.00 |
| Total | 110.84 | |
| Bench | ||
| Pos | Player | Points |
| BN | Dak Prescott QB | 0.00 |
| BN | Tyler Lockett WR | 20.20 |
| BN | Allen Robinson WR | 3.60 |
| BN | Atlanta Falcons DST | 2.00 |
| BN | Samaje Perine RB | 2.60 |
| BN | Royce Freeman RB | 2.50 |
| BN | Justin Jackson RB | 7.90 |
| BN | Tyler Conklin TE | 8.20 |
| BN | Darius Slayton WR | 0.00 |
| BN | Tim Patrick WR | 7.90 |
| Bench | ||
| Pos | Player | Points |
| BN | Mark Ingram RB | 6.20 |
| BN | Antonio Brown WR | 0.00 |
| BN | Melvin Gordon RB | 17.70 |
| BN | Las Vegas Raiders DST | 0.00 |
| BN | Josh Jacobs RB | 0.00 |
| BN | Bryan Edwards WR | 0.00 |
| BN | Laviska Shenault Jr. WR | 3.10 |
| BN | Tua Tagovailoa QB | 13.20 |
| BN | Trey Sermon RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jimmy Garoppolo QB | 27.28 | 43.1% |
| RB | Darrel Williams RB | 14.00 | 100% |
| RB | Chuba Hubbard RB | 13.60 | |
| WR | Michael Pittman Jr. WR | 25.60 | 81.4% |
| WR | Tyler Lockett WR | 20.20 | |
| TE | Tyler Conklin TE | 8.20 | 48.8% |
| FLEX | Adam Thielen WR | 16.80 | 74% |
| FLEX | Tee Higgins WR | 11.70 | |
| DST | Buffalo Bills DST | 11.00 | 100% |
| Total | 148.38 | 76% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Ben Roethlisberger QB | 16.64 | 24.9% |
| RB | Joe Mixon RB | 23.10 | 98.2% |
| RB | Melvin Gordon RB | 17.70 | |
| WR | D.K. Metcalf WR | 19.30 | 80.7% |
| WR | CeeDee Lamb WR | 14.05 | |
| TE | T.J. Hockenson TE | 13.90 | 100% |
| FLEX | Cordarrelle Patterson RB | 16.95 | 90.3% |
| FLEX | Diontae Johnson WR | 12.80 | |
| DST | Las Vegas Raiders DST | 0.00 | -- |
| Total | 134.44 | 82.4% | |