| Starters | ||
| Pos | Player | Points |
| QB | Kyler Murray QB | 5.06 |
| RB | Ronald Jones II RB | 2.40 |
| RB | Michael Carter RB | 27.70 |
| WR | Odell Beckham WR | 1.10 |
| WR | Mike Evans WR | 11.80 |
| TE | Jonnu Smith TE | 2.30 |
| FLEX | Dalvin Cook RB | 7.80 |
| FLEX | Christian Kirk WR | 6.60 |
| DST | Jacksonville Jaguars DST | 4.00 |
| Total | 68.76 | |
| Starters | ||
| Pos | Player | Points |
| QB | Josh Allen QB | 33.46 |
| RB | Leonard Fournette RB | 5.80 |
| RB | Aaron Jones RB | 20.50 |
| WR | Sterling Shepard WR | 4.50 |
| WR | Keenan Allen WR | 16.70 |
| TE | Ricky Seals-Jones TE | 2.20 |
| FLEX | Marvin Jones WR | 6.00 |
| FLEX | Elijah Mitchell RB | 19.70 |
| DST | Cincinnati Bengals DST | 1.00 |
| Total | 109.86 | |
| Bench | ||
| Pos | Player | Points |
| BN | Tom Brady QB | 29.20 |
| BN | Todd Gurley RB | 0.00 |
| BN | New England Patriots DST | 12.00 |
| BN | Sony Michel RB | 6.60 |
| BN | Hayden Hurst TE | 1.40 |
| BN | Benny Snell Jr. RB | 1.20 |
| BN | Alexander Mattison RB | 1.00 |
| BN | K.J. Hamler WR | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Pittsburgh Steelers DST | 9.00 |
| BN | Amari Cooper WR | 22.20 |
| BN | Davante Adams WR | 0.00 |
| BN | Seattle Seahawks DST | 12.00 |
| BN | Kirk Cousins QB | 15.16 |
| BN | James Conner RB | 14.20 |
| BN | Dalton Schultz TE | 2.10 |
| BN | Daniel Jones QB | 18.08 |
| BN | Marquez Callaway WR | 4.50 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Tom Brady QB | 29.20 | 17.3% |
| RB | Michael Carter RB | 27.70 | 84.8% |
| RB | Dalvin Cook RB | 7.80 | |
| WR | Mike Evans WR | 11.80 | 57.1% |
| WR | TreQuan Smith WR | 10.80 | |
| TE | Jonnu Smith TE | 2.30 | 100% |
| FLEX | Nico Collins WR | 7.50 | 102.1% |
| FLEX | Sony Michel RB | 6.60 | |
| DST | New England Patriots DST | 12.00 | 33.3% |
| Total | 115.7 | 59.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Josh Allen QB | 33.46 | 100% |
| RB | Aaron Jones RB | 20.50 | 65.4% |
| RB | Elijah Mitchell RB | 19.70 | |
| WR | Amari Cooper WR | 22.20 | 54.5% |
| WR | Keenan Allen WR | 16.70 | |
| TE | Ricky Seals-Jones TE | 2.20 | 100% |
| FLEX | James Conner RB | 14.20 | 96.6% |
| FLEX | Jamison Crowder WR | 12.40 | |
| DST | Seattle Seahawks DST | 12.00 | 8.3% |
| Total | 153.36 | 71.6% | |