| Starters | ||
| Pos | Player | Points |
| QB | Matthew Stafford QB | 11.06 |
| RB | Nyheim Hines RB | 20.05 |
| RB | Kenneth Gainwell RB | 6.30 |
| WR | Stefon Diggs WR | 11.50 |
| WR | Cooper Kupp WR | 15.00 |
| TE | Mark Andrews TE | 6.90 |
| FLEX | Jakobi Meyers WR | 1.65 |
| FLEX | Deebo Samuel WR | 8.80 |
| DST | Indianapolis Colts DST | 0.00 |
| Total | 81.26 | |
| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 35.64 |
| RB | Melvin Gordon RB | 16.50 |
| RB | Joshua Kelley RB | 1.50 |
| WR | Robby Anderson WR | 0.70 |
| WR | Jalen Reagor WR | -0.10 |
| TE | Kyle Pitts TE | 7.70 |
| FLEX | Tyler Boyd WR | 1.60 |
| FLEX | Brandin Cooks WR | 8.60 |
| DST | Denver Broncos DST | 7.00 |
| Total | 79.14 | |
| Bench | ||
| Pos | Player | Points |
| BN | Josh Gordon WR | 0.00 |
| BN | Cleveland Browns DST | 18.00 |
| BN | Kenny Golladay WR | 3.80 |
| BN | C.J. Uzomah TE | 4.40 |
| BN | Calvin Ridley WR | 0.00 |
| BN | Donovan Peoples-Jones WR | 15.60 |
| BN | Jalen Hurts QB | 18.68 |
| BN | Antonio Gibson RB | 0.00 |
| BN | Rhamondre Stevenson RB | 11.60 |
| BN | Larry Rountree RB | 0.10 |
| Bench | ||
| Pos | Player | Points |
| BN | Eric Ebron TE | 0.00 |
| BN | A.J. Green WR | 0.00 |
| BN | Sammy Watkins WR | 0.00 |
| BN | Marlon Mack RB | 0.00 |
| BN | Derrius Guice RB | 0.00 |
| BN | Antonio Gandy-Golden TE | 0.00 |
| BN | Quintez Cephus WR | 0.00 |
| BN | Javian Hawkins RB | 0.00 |
| BN | Jermar Jefferson RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jalen Hurts QB | 18.68 | 59.2% |
| RB | Nyheim Hines RB | 20.05 | 83.3% |
| RB | Rhamondre Stevenson RB | 11.60 | |
| WR | Donovan Peoples-Jones WR | 15.60 | 86.6% |
| WR | Cooper Kupp WR | 15.00 | |
| TE | Mark Andrews TE | 6.90 | 100% |
| FLEX | Stefon Diggs WR | 11.50 | 51.5% |
| FLEX | Deebo Samuel WR | 8.80 | |
| DST | Cleveland Browns DST | 18.00 | 0% |
| Total | 126.13 | 64.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 35.64 | 100% |
| RB | Melvin Gordon RB | 16.50 | 100% |
| RB | Joshua Kelley RB | 1.50 | |
| WR | Jerry Jeudy WR | 9.90 | 3.2% |
| WR | Brandin Cooks WR | 8.60 | |
| TE | Kyle Pitts TE | 7.70 | 100% |
| FLEX | Tyler Boyd WR | 1.60 | 443.5% |
| FLEX | Robby Anderson WR | 0.70 | |
| DST | Denver Broncos DST | 7.00 | 100% |
| Total | 89.14 | 88.8% | |