| Starters | ||
| Pos | Player | Points |
| QB | Patrick Mahomes QB | 46.24 |
| RB | Devin Singletary RB | 11.40 |
| RB | Najee Harris RB | 15.30 |
| WR | Tyreek Hill WR | 24.00 |
| WR | Rashod Bateman WR | 11.00 |
| TE | Zach Ertz TE | 6.60 |
| FLEX | Jarvis Landry WR | 4.60 |
| FLEX | Mike Davis RB | 1.80 |
| DST | Baltimore Ravens DST | 4.00 |
| Total | 124.94 | |
| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 12.00 |
| RB | Melvin Gordon RB | 8.80 |
| RB | Joshua Kelley RB | 0.60 |
| WR | Robby Anderson WR | 11.70 |
| WR | Jalen Reagor WR | 1.35 |
| TE | Kyle Pitts TE | 8.00 |
| FLEX | A.J. Green WR | 0.90 |
| FLEX | Jermar Jefferson RB | 10.10 |
| DST | Denver Broncos DST | 2.00 |
| Total | 55.45 | |
| Bench | ||
| Pos | Player | Points |
| BN | Chicago Bears DST | 0.00 |
| BN | Derek Carr QB | 20.24 |
| BN | Austin Hooper TE | 10.50 |
| BN | Matt Breida RB | 16.50 |
| BN | J.D. McKissic RB | 5.90 |
| BN | Anthony Miller WR | 0.00 |
| BN | Justice Hill RB | 0.00 |
| BN | Henry Ruggs III WR | 0.00 |
| BN | Chase Claypool WR | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Eric Ebron TE | 2.30 |
| BN | Tyler Boyd WR | 0.00 |
| BN | Sammy Watkins WR | -0.80 |
| BN | Brandin Cooks WR | 0.00 |
| BN | Marlon Mack RB | 0.00 |
| BN | Derrius Guice RB | 0.00 |
| BN | Antonio Gandy-Golden TE | 0.00 |
| BN | Quintez Cephus WR | 0.00 |
| BN | Javian Hawkins RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Patrick Mahomes QB | 46.24 | 100% |
| RB | Matt Breida RB | 16.50 | 84% |
| RB | Najee Harris RB | 15.30 | |
| WR | Tyreek Hill WR | 24.00 | 100% |
| WR | Rashod Bateman WR | 11.00 | |
| TE | Austin Hooper TE | 10.50 | 62.9% |
| FLEX | Devin Singletary RB | 11.40 | 35.6% |
| FLEX | Zach Ertz TE | 6.60 | |
| DST | Baltimore Ravens DST | 4.00 | 100% |
| Total | 145.54 | 85.8% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 12.00 | 100% |
| RB | Jermar Jefferson RB | 10.10 | 49.7% |
| RB | Melvin Gordon RB | 8.80 | |
| WR | Robby Anderson WR | 11.70 | 65.9% |
| WR | Jerry Jeudy WR | 8.10 | |
| TE | Kyle Pitts TE | 8.00 | 100% |
| FLEX | Eric Ebron TE | 2.30 | 301.4% |
| FLEX | Jalen Reagor WR | 1.35 | |
| DST | Denver Broncos DST | 2.00 | 100% |
| Total | 64.35 | 86.2% | |