| Starters | ||
| Pos | Player | Points |
| RB | Tevin Coleman RB | 8.00 |
| RB | Sony Michel RB | 7.50 |
| WR | Odell Beckham WR | 16.60 |
| WR | Mike Evans WR | 3.10 |
| TE | Jonnu Smith TE | 7.30 |
| FLEX | Dalvin Cook RB | 11.30 |
| FLEX | TreQuan Smith WR | 5.10 |
| DST | New England Patriots DST | 12.00 |
| Total | 70.9 | |
| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 19.72 |
| RB | Melvin Gordon RB | 9.30 |
| RB | Joshua Kelley RB | 3.00 |
| WR | Tyler Boyd WR | 2.30 |
| WR | Robby Anderson WR | 2.00 |
| TE | Kyle Pitts TE | 3.60 |
| FLEX | Brandin Cooks WR | 12.00 |
| FLEX | Jermar Jefferson RB | 0.00 |
| DST | Denver Broncos DST | 15.00 |
| Total | 66.92 | |
| Bench | ||
| Pos | Player | Points |
| BN | Jacksonville Jaguars DST | 3.00 |
| BN | Todd Gurley RB | 0.00 |
| BN | Ronald Jones II RB | 9.70 |
| BN | Hayden Hurst TE | 0.00 |
| BN | Christian Kirk WR | 0.00 |
| BN | Kyler Murray QB | 0.00 |
| BN | Benny Snell Jr. RB | 0.50 |
| BN | Alexander Mattison RB | 10.70 |
| BN | Michael Carter RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Eric Ebron TE | 0.00 |
| BN | A.J. Green WR | 0.00 |
| BN | Sammy Watkins WR | 1.30 |
| BN | Marlon Mack RB | 0.00 |
| BN | Derrius Guice RB | 0.00 |
| BN | Antonio Gandy-Golden TE | 0.00 |
| BN | Jalen Reagor WR | 6.95 |
| BN | Quintez Cephus WR | 0.00 |
| BN | Javian Hawkins RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Mac Jones QB | 25.50 | 0% |
| RB | Dalvin Cook RB | 11.30 | 70.5% |
| RB | Alexander Mattison RB | 10.70 | |
| WR | Odell Beckham WR | 16.60 | 71.9% |
| WR | T.Y. Hilton WR | 10.80 | |
| TE | Jonnu Smith TE | 7.30 | 100% |
| FLEX | Ronald Jones II RB | 9.70 | 92.7% |
| FLEX | Tevin Coleman RB | 8.00 | |
| DST | New England Patriots DST | 12.00 | 100% |
| Total | 111.9 | 63.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 19.72 | 100% |
| RB | Melvin Gordon RB | 9.30 | 100% |
| RB | Joshua Kelley RB | 3.00 | |
| WR | Brandin Cooks WR | 12.00 | 22.7% |
| WR | Jalen Reagor WR | 6.95 | |
| TE | Kyle Pitts TE | 3.60 | 100% |
| FLEX | Jerry Jeudy WR | 3.50 | 206.9% |
| FLEX | Tyler Boyd WR | 2.30 | |
| DST | Denver Broncos DST | 15.00 | 100% |
| Total | 75.37 | 88.8% | |