| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 30.90 |
| RB | Melvin Gordon RB | 23.10 |
| RB | Jermar Jefferson RB | 0.00 |
| WR | Tyler Boyd WR | 8.35 |
| WR | Robby Anderson WR | 17.90 |
| TE | Kyle Pitts TE | 8.60 |
| FLEX | A.J. Green WR | 13.70 |
| FLEX | Brandin Cooks WR | 14.10 |
| DST | Denver Broncos DST | 9.00 |
| Total | 125.65 | |
| Starters | ||
| Pos | Player | Points |
| QB | Matthew Stafford QB | 29.48 |
| RB | James Conner RB | 29.00 |
| RB | Aaron Jones RB | 20.00 |
| WR | Stefon Diggs WR | 10.90 |
| WR | Cooper Kupp WR | 24.80 |
| TE | Mark Andrews TE | 23.00 |
| FLEX | Deebo Samuel WR | 12.40 |
| FLEX | Donovan Peoples-Jones WR | 11.50 |
| DST | Pittsburgh Steelers DST | -4.00 |
| Total | 157.08 | |
| Bench | ||
| Pos | Player | Points |
| BN | Eric Ebron TE | 0.00 |
| BN | Sammy Watkins WR | 0.00 |
| BN | Marlon Mack RB | 0.00 |
| BN | Derrius Guice RB | 0.00 |
| BN | Antonio Gandy-Golden TE | 0.00 |
| BN | Joshua Kelley RB | 4.30 |
| BN | Jalen Reagor WR | 0.00 |
| BN | Javian Hawkins RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Indianapolis Colts DST | 0.00 |
| BN | Kenny Golladay WR | 2.50 |
| BN | Calvin Ridley WR | 0.00 |
| BN | Jakobi Meyers WR | 0.00 |
| BN | DErnest Johnson RB | 3.40 |
| BN | Miles Sanders RB | 0.00 |
| BN | Jalen Hurts QB | 0.00 |
| BN | Rhamondre Stevenson RB | 0.00 |
| BN | Kenneth Gainwell RB | 0.00 |
| BN | Larry Rountree RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 30.90 | 100% |
| RB | Melvin Gordon RB | 23.10 | 56.6% |
| RB | Clyde Edwards-Helaire RB | 17.70 | |
| WR | Robby Anderson WR | 17.90 | 82% |
| WR | Brandin Cooks WR | 14.10 | |
| TE | Kyle Pitts TE | 8.60 | 100% |
| FLEX | A.J. Green WR | 13.70 | 126.1% |
| FLEX | Tyler Boyd WR | 8.35 | |
| DST | Denver Broncos DST | 9.00 | 100% |
| Total | 143.35 | 87.7% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Matthew Stafford QB | 29.48 | 100% |
| RB | James Conner RB | 29.00 | 100% |
| RB | Aaron Jones RB | 20.00 | |
| WR | Cooper Kupp WR | 24.80 | 96% |
| WR | Deebo Samuel WR | 12.40 | |
| TE | Mark Andrews TE | 23.00 | 100% |
| FLEX | Donovan Peoples-Jones WR | 11.50 | 106.7% |
| FLEX | Stefon Diggs WR | 10.90 | |
| DST | Indianapolis Colts DST | 0.00 | -- |
| Total | 161.08 | 97.5% | |