| Starters | ||
| Pos | Player | Points |
| QB | Kyler Murray QB | 24.62 |
| RB | Aaron Jones RB | 9.10 |
| RB | Ronald Jones II RB | 0.00 |
| WR | Mike Evans WR | 15.60 |
| WR | Christian Kirk WR | 14.70 |
| WR | K.J. Hamler WR | 0.00 |
| TE | Cole Kmet TE | 0.00 |
| FLEX | Michael Carter RB | 13.50 |
| FLEX | Dameon Pierce RB | 4.40 |
| DST | New England Patriots DST | 4.00 |
| Total | 85.92 | |
| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 29.26 |
| RB | Dalvin Cook RB | 12.30 |
| RB | Clyde Edwards-Helaire RB | 20.90 |
| WR | Brandin Cooks WR | 11.70 |
| WR | JuJu Smith-Schuster WR | 8.90 |
| WR | Jerry Jeudy WR | 18.20 |
| TE | Kyle Pitts TE | 2.90 |
| FLEX | Melvin Gordon RB | 6.20 |
| FLEX | Breece Hall RB | 7.10 |
| DST | Denver Broncos DST | 7.00 |
| Total | 124.46 | |
| Bench | ||
| Pos | Player | Points |
| BN | Tevin Coleman RB | 0.00 |
| BN | T.Y. Hilton WR | 0.00 |
| BN | Odell Beckham WR | 0.00 |
| BN | Jameis Winston QB | 25.66 |
| BN | Kansas City Chiefs DST | 5.00 |
| BN | Jonnu Smith TE | 4.80 |
| BN | Sony Michel RB | 1.20 |
| BN | TreQuan Smith WR | 0.00 |
| BN | Kenneth Walker RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | A.J. Green WR | 2.30 |
| BN | Tyler Boyd WR | 11.30 |
| BN | Sammy Watkins WR | 3.30 |
| BN | Marlon Mack RB | 0.00 |
| BN | Quintez Cephus WR | 0.00 |
| BN | Zach Wilson QB | 0.00 |
| BN | Rachaad White RB | 3.10 |
| BN | David Bell WR | 0.00 |
| BN | Isaiah Spiller RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jameis Winston QB | 25.66 | 95.9% |
| RB | Michael Carter RB | 13.50 | 40.3% |
| RB | Aaron Jones RB | 9.10 | |
| WR | Mike Evans WR | 15.60 | 100% |
| WR | Christian Kirk WR | 14.70 | |
| TE | Jonnu Smith TE | 4.80 | 0% |
| FLEX | Dameon Pierce RB | 4.40 | 319.6% |
| FLEX | Sony Michel RB | 1.20 | |
| DST | Kansas City Chiefs DST | 5.00 | 80% |
| Total | 93.96 | 91.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 29.26 | 100% |
| RB | Clyde Edwards-Helaire RB | 20.90 | 100% |
| RB | Dalvin Cook RB | 12.30 | |
| WR | Jerry Jeudy WR | 18.20 | 129.8% |
| WR | Brandin Cooks WR | 11.70 | |
| TE | Kyle Pitts TE | 2.90 | 100% |
| FLEX | Tyler Boyd WR | 11.30 | 65.8% |
| FLEX | JuJu Smith-Schuster WR | 8.90 | |
| DST | Denver Broncos DST | 7.00 | 100% |
| Total | 122.46 | 101.6% | |