| Starters | ||
| Pos | Player | Points |
| QB | Marcus Mariota QB | 18.80 |
| RB | Eddie Lacy RB | 0.30 |
| RB | Latavius Murray RB | 0.60 |
| WR | Kelvin Benjamin WR | 3.00 |
| WR | Pierre Garcon WR | 11.10 |
| TE | Greg Olsen TE | 2.80 |
| FLEX | Chris Hogan WR | 3.00 |
| FLEX | Tyrell Williams WR | 7.90 |
| DST | Pittsburgh Steelers DST | 19.00 |
| Total | 66.5 | |
| Starters | ||
| Pos | Player | Points |
| QB | Matthew Stafford QB | 27.10 |
| RB | C.J. Anderson RB | 9.30 |
| RB | Leonard Fournette RB | 19.90 |
| WR | DeAndre Hopkins WR | 15.00 |
| WR | Terrelle Pryor WR | 9.60 |
| TE | Rob Gronkowski TE | 4.30 |
| FLEX | Randall Cobb WR | 13.00 |
| FLEX | Eric Decker WR | 2.50 |
| DST | Houston Texans DST | 2.00 |
| Total | 102.7 | |
| Bench | ||
| Pos | Player | Points |
| BN | Deshaun Watson QB | 5.70 |
| BN | Carson Palmer QB | 8.90 |
| BN | Trevor Siemian QB | 22.70 |
| BN | Dion Lewis RB | 3.40 |
| BN | ArDarius Stewart WR | 2.00 |
| BN | J.J. Nelson WR | 12.80 |
| BN | Evan Engram TE | 6.40 |
| BN | Arizona Cardinals DST | 7.00 |
| BN | Charcandrick West RB | 9.00 |
| BN | Victor Cruz WR | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Paul Perkins RB | 3.50 |
| BN | Darren Sproles RB | 7.00 |
| BN | Kevin White WR | 1.60 |
| BN | DeVante Parker WR | 0.00 |
| BN | Mike Williams WR | 0.00 |
| BN | Marqise Lee WR | 0.40 |
| BN | Kenny Golladay WR | 20.90 |
| BN | O.J. Howard TE | 0.00 |
| BN | Devin Funchess TE | 3.00 |
| BN | Paul Richardson WR | 7.90 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Trevor Siemian QB | 22.70 | 82.8% |
| RB | Charcandrick West RB | 9.00 | 7.3% |
| RB | Dion Lewis RB | 3.40 | |
| WR | J.J. Nelson WR | 12.80 | 59% |
| WR | Pierre Garcon WR | 11.10 | |
| TE | Evan Engram TE | 6.40 | 43.8% |
| FLEX | Tyrell Williams WR | 7.90 | 100% |
| FLEX | Kelvin Benjamin WR | 3.00 | |
| DST | Pittsburgh Steelers DST | 19.00 | 100% |
| Total | 95.3 | 69.8% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Matthew Stafford QB | 27.10 | 100% |
| RB | Leonard Fournette RB | 19.90 | 100% |
| RB | C.J. Anderson RB | 9.30 | |
| WR | Kenny Golladay WR | 20.90 | 68.5% |
| WR | DeAndre Hopkins WR | 15.00 | |
| TE | Rob Gronkowski TE | 4.30 | 100% |
| FLEX | Randall Cobb WR | 13.00 | 68.6% |
| FLEX | Terrelle Pryor WR | 9.60 | |
| DST | Houston Texans DST | 2.00 | 100% |
| Total | 121.1 | 84.8% | |