| Starters | ||
| Pos | Player | Points |
| QB | Patrick Mahomes QB | 38.48 |
| RB | Devin Singletary RB | 5.10 |
| RB | Najee Harris RB | 5.10 |
| WR | Tyreek Hill WR | 9.40 |
| WR | Chase Claypool WR | 7.50 |
| WR | Drake London WR | 5.50 |
| TE | Zach Ertz TE | 7.80 |
| FLEX | J.D. McKissic RB | 6.20 |
| FLEX | J.K. Dobbins RB | 4.40 |
| DST | Baltimore Ravens DST | 8.00 |
| Total | 97.48 | |
| Starters | ||
| Pos | Player | Points |
| QB | Josh Allen QB | 41.16 |
| RB | Leonard Fournette RB | 30.90 |
| RB | Christian McCaffrey RB | 19.90 |
| WR | Amari Cooper WR | 17.10 |
| WR | Davante Adams WR | 25.90 |
| WR | Curtis Samuel WR | 9.20 |
| TE | Dalton Schultz TE | 0.00 |
| FLEX | Raheem Mostert RB | 18.70 |
| FLEX | Nyheim Hines RB | 1.30 |
| DST | Tampa Bay Buccaneers DST | 8.00 |
| Total | 172.16 | |
| Bench | ||
| Pos | Player | Points |
| BN | Chicago Bears DST | 1.00 |
| BN | Derek Carr QB | 21.94 |
| BN | Jarvis Landry WR | 0.00 |
| BN | Mike Gesicki TE | 3.50 |
| BN | Justice Hill RB | 0.00 |
| BN | Rashod Bateman WR | 0.00 |
| BN | Jahan Dotson WR | 0.00 |
| BN | Jalen Tolbert WR | 0.00 |
| BN | Kyren Williams RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Marcus Mariota QB | 19.98 |
| BN | DeAndre Hopkins WR | 0.00 |
| BN | Keenan Allen WR | 0.00 |
| BN | Seattle Seahawks DST | -1.00 |
| BN | Cincinnati Bengals DST | 3.00 |
| BN | Kirk Cousins QB | 22.24 |
| BN | Corey Davis WR | 4.80 |
| BN | Logan Thomas TE | 0.00 |
| BN | Antonio Gibson RB | 5.40 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Patrick Mahomes QB | 38.48 | 100% |
| RB | J.D. McKissic RB | 6.20 | 90.3% |
| RB | Devin Singletary RB | 5.10 | |
| WR | Tyreek Hill WR | 9.40 | 132.5% |
| WR | Chase Claypool WR | 7.50 | |
| TE | Zach Ertz TE | 7.80 | 100% |
| FLEX | Drake London WR | 5.50 | 100% |
| FLEX | Najee Harris RB | 5.10 | |
| DST | Baltimore Ravens DST | 8.00 | 100% |
| Total | 93.08 | 104.7% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Josh Allen QB | 41.16 | 100% |
| RB | Leonard Fournette RB | 30.90 | 100% |
| RB | Christian McCaffrey RB | 19.90 | |
| WR | Davante Adams WR | 25.90 | 121.4% |
| WR | Amari Cooper WR | 17.10 | |
| TE | Dalton Schultz TE | 0.00 | -- |
| FLEX | Raheem Mostert RB | 18.70 | 71.3% |
| FLEX | Velus Jones WR | 9.35 | |
| DST | Tampa Bay Buccaneers DST | 8.00 | 100% |
| Total | 171.01 | 100.7% | |