| Starters | ||
| Pos | Player | Points |
| QB | Jalen Hurts QB | 20.90 |
| RB | Jeff Wilson Jr. RB | 0.50 |
| RB | Rhamondre Stevenson RB | 23.10 |
| WR | Stefon Diggs WR | 25.80 |
| WR | Cooper Kupp WR | 13.20 |
| WR | Deebo Samuel WR | 12.50 |
| TE | Mark Andrews TE | 20.10 |
| FLEX | Ezekiel Elliott RB | 15.10 |
| FLEX | Miles Sanders RB | 13.70 |
| DST | New Orleans Saints DST | 4.00 |
| Total | 148.9 | |
| Starters | ||
| Pos | Player | Points |
| QB | Josh Allen QB | 32.36 |
| RB | Leonard Fournette RB | 19.10 |
| RB | Christian McCaffrey RB | 19.30 |
| WR | Amari Cooper WR | 12.40 |
| WR | Curtis Samuel WR | 1.60 |
| WR | Adam Thielen WR | 13.60 |
| TE | Tyler Higbee TE | 1.20 |
| FLEX | Corey Davis WR | 6.20 |
| FLEX | Raheem Mostert RB | 6.55 |
| DST | Tampa Bay Buccaneers DST | 4.00 |
| Total | 116.31 | |
| Bench | ||
| Pos | Player | Points |
| BN | Buffalo Bills DST | 6.00 |
| BN | Matthew Stafford QB | 11.82 |
| BN | David Njoku TE | 7.30 |
| BN | Calvin Ridley WR | 0.00 |
| BN | Gus Edwards RB | 0.00 |
| BN | Jakobi Meyers WR | 8.00 |
| BN | Mike Boone RB | 0.90 |
| BN | Kenneth Gainwell RB | 2.50 |
| BN | Jaylen Warren RB | 0.20 |
| Bench | ||
| Pos | Player | Points |
| BN | Marcus Mariota QB | 28.16 |
| BN | DeAndre Hopkins WR | 0.00 |
| BN | Davante Adams WR | 0.00 |
| BN | Keenan Allen WR | 0.00 |
| BN | Cincinnati Bengals DST | 0.00 |
| BN | Kirk Cousins QB | 20.50 |
| BN | Nyheim Hines RB | 0.00 |
| BN | Dalton Schultz TE | 0.00 |
| BN | Antonio Gibson RB | 8.15 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jalen Hurts QB | 20.90 | 100% |
| RB | Rhamondre Stevenson RB | 23.10 | 61.8% |
| RB | Ezekiel Elliott RB | 15.10 | |
| WR | Stefon Diggs WR | 25.80 | 132.1% |
| WR | Cooper Kupp WR | 13.20 | |
| TE | Mark Andrews TE | 20.10 | 100% |
| FLEX | Miles Sanders RB | 13.70 | 109.9% |
| FLEX | Deebo Samuel WR | 12.50 | |
| DST | Buffalo Bills DST | 6.00 | 66.7% |
| Total | 150.4 | 99% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Josh Allen QB | 32.36 | 100% |
| RB | Christian McCaffrey RB | 19.30 | 100% |
| RB | Leonard Fournette RB | 19.10 | |
| WR | Adam Thielen WR | 13.60 | 106.2% |
| WR | Amari Cooper WR | 12.40 | |
| TE | Tyler Higbee TE | 1.20 | 100% |
| FLEX | Antonio Gibson RB | 8.15 | 86.7% |
| FLEX | Raheem Mostert RB | 6.55 | |
| DST | Tampa Bay Buccaneers DST | 4.00 | 100% |
| Total | 116.66 | 99.7% | |