| Starters | ||
| Pos | Player | Points |
| QB | Derek Carr QB | -0.06 |
| RB | Devin Singletary RB | 8.80 |
| RB | Najee Harris RB | 8.96 |
| WR | Tyreek Hill WR | 25.50 |
| WR | Chase Claypool WR | 12.54 |
| WR | Drake London WR | 5.10 |
| TE | Zach Ertz TE | 11.40 |
| FLEX | Mike Gesicki TE | 11.30 |
| FLEX | Rashod Bateman WR | 0.00 |
| DST | Baltimore Ravens DST | 5.00 |
| Total | 88.54 | |
| Starters | ||
| Pos | Player | Points |
| QB | Geno Smith QB | 23.08 |
| RB | Derrick Henry RB | 35.30 |
| RB | Brian Robinson RB | 2.00 |
| WR | Devin Duvernay WR | 19.35 |
| WR | Amon-Ra St. Brown WR | 10.40 |
| WR | Garrett Wilson WR | 14.50 |
| TE | Dallas Goedert TE | 9.40 |
| FLEX | Jamaal Williams RB | 21.10 |
| FLEX | Taysom Hill TE | 7.78 |
| DST | Arizona Cardinals DST | 5.00 |
| Total | 147.91 | |
| Bench | ||
| Pos | Player | Points |
| BN | Chicago Bears DST | -3.00 |
| BN | Jarvis Landry WR | 0.00 |
| BN | Patrick Mahomes QB | 0.00 |
| BN | J.D. McKissic RB | 3.50 |
| BN | Justice Hill RB | 2.80 |
| BN | J.K. Dobbins RB | 0.00 |
| BN | Jahan Dotson WR | 0.00 |
| BN | Jalen Tolbert WR | 0.00 |
| BN | Tyquan Thornton WR | 1.80 |
| Bench | ||
| Pos | Player | Points |
| BN | Travis Kelce TE | 0.00 |
| BN | Los Angeles Chargers DST | 0.00 |
| BN | Carson Wentz QB | 0.00 |
| BN | Austin Ekeler RB | 0.00 |
| BN | Allen Lazard WR | 0.00 |
| BN | Russell Gage WR | 0.00 |
| BN | Mecole Hardman WR | 0.00 |
| BN | Cam Akers RB | 0.00 |
| BN | Skyy Moore WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Patrick Mahomes QB | 0.00 | 0% |
| RB | Najee Harris RB | 8.96 | 100% |
| RB | Devin Singletary RB | 8.80 | |
| WR | Tyreek Hill WR | 25.50 | 113.4% |
| WR | Chase Claypool WR | 12.54 | |
| TE | Zach Ertz TE | 11.40 | 100% |
| FLEX | Mike Gesicki TE | 11.30 | 68.9% |
| FLEX | Drake London WR | 5.10 | |
| DST | Baltimore Ravens DST | 5.00 | 100% |
| Total | 88.6 | 99.9% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Geno Smith QB | 23.08 | 100% |
| RB | Derrick Henry RB | 35.30 | 66.1% |
| RB | Jamaal Williams RB | 21.10 | |
| WR | Devin Duvernay WR | 19.35 | 130.7% |
| WR | Garrett Wilson WR | 14.50 | |
| TE | Dallas Goedert TE | 9.40 | 100% |
| FLEX | Amon-Ra St. Brown WR | 10.40 | 158.9% |
| FLEX | Taysom Hill TE | 7.78 | |
| DST | Arizona Cardinals DST | 5.00 | 100% |
| Total | 145.91 | 101.4% | |