| Starters | ||
| Pos | Player | Points |
| QB | Kyler Murray QB | 26.64 |
| RB | Aaron Jones RB | 17.70 |
| RB | Kenneth Walker RB | 11.70 |
| WR | Mike Evans WR | 15.30 |
| WR | Christian Kirk WR | 6.75 |
| WR | K.J. Hamler WR | 7.10 |
| TE | Cole Kmet TE | 8.10 |
| FLEX | Michael Carter RB | 8.10 |
| FLEX | Dameon Pierce RB | 12.60 |
| DST | New England Patriots DST | 8.00 |
| Total | 121.99 | |
| Starters | ||
| Pos | Player | Points |
| QB | Josh Allen QB | 17.62 |
| RB | Christian McCaffrey RB | 38.26 |
| RB | Raheem Mostert RB | 7.85 |
| WR | DeAndre Hopkins WR | 27.90 |
| WR | Amari Cooper WR | 17.60 |
| WR | Davante Adams WR | 0.70 |
| TE | Tyler Higbee TE | 2.50 |
| FLEX | Leonard Fournette RB | 13.30 |
| FLEX | Adam Thielen WR | 9.70 |
| DST | Cincinnati Bengals DST | 4.00 |
| Total | 139.43 | |
| Bench | ||
| Pos | Player | Points |
| BN | Josh Gordon WR | 0.00 |
| BN | Tevin Coleman RB | 0.00 |
| BN | Odell Beckham WR | 0.00 |
| BN | Nelson Agholor WR | 0.70 |
| BN | Jameis Winston QB | 0.00 |
| BN | Kansas City Chiefs DST | 0.00 |
| BN | O.J. Howard TE | 3.40 |
| BN | Jonnu Smith TE | 3.30 |
| BN | Sony Michel RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Marcus Mariota QB | 24.42 |
| BN | Keenan Allen WR | 0.00 |
| BN | Kirk Cousins QB | 27.48 |
| BN | Tampa Bay Buccaneers DST | 0.00 |
| BN | DOnta Foreman RB | 31.80 |
| BN | Curtis Samuel WR | 9.40 |
| BN | Nyheim Hines RB | 11.90 |
| BN | Dalton Schultz TE | 10.40 |
| BN | Antonio Gibson RB | 19.25 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kyler Murray QB | 26.64 | 100% |
| RB | Aaron Jones RB | 17.70 | 97% |
| RB | Dameon Pierce RB | 12.60 | |
| WR | Mike Evans WR | 15.30 | 130.1% |
| WR | K.J. Hamler WR | 7.10 | |
| TE | Cole Kmet TE | 8.10 | 100% |
| FLEX | Kenneth Walker RB | 11.70 | 104.5% |
| FLEX | Michael Carter RB | 8.10 | |
| DST | New England Patriots DST | 8.00 | 100% |
| Total | 115.24 | 105.9% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kirk Cousins QB | 27.48 | 64.1% |
| RB | Christian McCaffrey RB | 38.26 | 65.8% |
| RB | DOnta Foreman RB | 31.80 | |
| WR | DeAndre Hopkins WR | 27.90 | 101.5% |
| WR | Amari Cooper WR | 17.60 | |
| TE | Dalton Schultz TE | 10.40 | 24% |
| FLEX | Antonio Gibson RB | 19.25 | 70.7% |
| FLEX | Leonard Fournette RB | 13.30 | |
| DST | Cincinnati Bengals DST | 4.00 | 100% |
| Total | 189.99 | 73.4% | |