| Starters | ||
| Pos | Player | Points |
| QB | Matthew Stafford QB | 12.50 |
| RB | Josh Jacobs RB | 10.20 |
| RB | Darrell Henderson RB | 5.60 |
| WR | D.K. Metcalf WR | 12.20 |
| WR | Brandon Aiyuk WR | 0.00 |
| WR | Alec Pierce WR | 2.80 |
| TE | T.J. Hockenson TE | 11.50 |
| FLEX | Eno Benjamin RB | 3.20 |
| FLEX | Pierre Strong RB | 0.00 |
| DST | Minnesota Vikings DST | 8.00 |
| Total | 66 | |
| Starters | ||
| Pos | Player | Points |
| QB | Geno Smith QB | 22.80 |
| RB | Derrick Henry RB | 23.50 |
| RB | Austin Ekeler RB | 20.60 |
| WR | Devin Duvernay WR | 1.00 |
| WR | Amon-Ra St. Brown WR | 7.50 |
| WR | Garrett Wilson WR | 13.90 |
| TE | Travis Kelce TE | 15.60 |
| FLEX | Jamaal Williams RB | 10.10 |
| FLEX | Allen Lazard WR | 16.70 |
| DST | Arizona Cardinals DST | 6.00 |
| Total | 137.7 | |
| Bench | ||
| Pos | Player | Points |
| BN | Mark Ingram RB | 0.00 |
| BN | Kenny Golladay WR | 0.00 |
| BN | Tennessee Titans DST | 1.00 |
| BN | Diontae Johnson WR | 0.00 |
| BN | Irv Smith Jr. TE | 0.00 |
| BN | CeeDee Lamb WR | 0.00 |
| BN | Donovan Peoples-Jones WR | 0.00 |
| BN | Mac Jones QB | 11.68 |
| BN | Zamir White RB | -0.10 |
| Bench | ||
| Pos | Player | Points |
| BN | Los Angeles Chargers DST | 7.00 |
| BN | Dallas Goedert TE | 20.00 |
| BN | Russell Gage WR | 0.00 |
| BN | Taysom Hill TE | 1.12 |
| BN | Mecole Hardman WR | 19.00 |
| BN | Cam Akers RB | 0.30 |
| BN | Skyy Moore WR | 0.00 |
| BN | Brian Robinson RB | 4.80 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Matthew Stafford QB | 12.50 | 100% |
| RB | Josh Jacobs RB | 10.20 | 100% |
| RB | Darrell Henderson RB | 5.60 | |
| WR | D.K. Metcalf WR | 12.20 | 67.3% |
| WR | Chris Olave WR | 10.10 | |
| TE | T.J. Hockenson TE | 11.50 | 100% |
| FLEX | Christian Watson WR | 3.40 | 48.5% |
| FLEX | Eno Benjamin RB | 3.20 | |
| DST | Minnesota Vikings DST | 8.00 | 100% |
| Total | 76.7 | 86% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Geno Smith QB | 22.80 | 100% |
| RB | Derrick Henry RB | 23.50 | 100% |
| RB | Austin Ekeler RB | 20.60 | |
| WR | Mecole Hardman WR | 19.00 | 62.7% |
| WR | Allen Lazard WR | 16.70 | |
| TE | Dallas Goedert TE | 20.00 | 78% |
| FLEX | Travis Kelce TE | 15.60 | 90.8% |
| FLEX | Garrett Wilson WR | 13.90 | |
| DST | Los Angeles Chargers DST | 7.00 | 85.7% |
| Total | 159.1 | 86.5% | |