| Starters | ||
| Pos | Player | Points |
| QB | Kirk Cousins QB | 27.60 |
| RB | Frank Gore RB | 6.60 |
| RB | Bilal Powell RB | 2.10 |
| WR | Jarvis Landry WR | 12.70 |
| WR | Golden Tate WR | 18.70 |
| TE | Tyler Kroft TE | 0.90 |
| FLEX | DeVante Parker WR | 9.60 |
| FLEX | DeSean Jackson WR | 11.20 |
| DST | Detroit Lions DST | 11.00 |
| Total | 100.4 | |
| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 14.00 |
| RB | Mark Ingram RB | 31.10 |
| RB | Tevin Coleman RB | 15.30 |
| WR | Antonio Brown WR | 6.60 |
| WR | Jordy Nelson WR | 3.50 |
| TE | Delanie Walker TE | 9.30 |
| FLEX | Robby Anderson WR | 16.50 |
| FLEX | Joe Mixon RB | 10.50 |
| DST | Tennessee Titans DST | 5.00 |
| Total | 111.8 | |
| Bench | ||
| Pos | Player | Points |
| BN | Taylor Gabriel WR | 8.80 |
| BN | Alex Smith QB | 0.00 |
| BN | LeGarrette Blount RB | 0.00 |
| BN | Ty Montgomery RB | 13.80 |
| BN | Kansas City Chiefs DST | 0.00 |
| BN | Marshawn Lynch RB | 0.00 |
| BN | Samaje Perine RB | 7.90 |
| BN | George Kittle TE | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Will Fuller WR | 2.50 |
| BN | Martavis Bryant WR | 6.80 |
| BN | Michael Crabtree WR | 0.00 |
| BN | Terrelle Pryor WR | 0.00 |
| BN | Los Angeles Chargers DST | 8.00 |
| BN | Rex Burkhead RB | 13.80 |
| BN | Deshaun Watson QB | 0.00 |
| BN | James Conner RB | 1.20 |
| BN | Damien Williams RB | 4.90 |
| BN | Matt Breida RB | 12.30 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kirk Cousins QB | 27.60 | 100% |
| RB | Ty Montgomery RB | 13.80 | 40.1% |
| RB | Samaje Perine RB | 7.90 | |
| WR | Golden Tate WR | 18.70 | 100% |
| WR | Jarvis Landry WR | 12.70 | |
| TE | Tyler Kroft TE | 0.90 | 100% |
| FLEX | DeSean Jackson WR | 11.20 | 100% |
| FLEX | DeVante Parker WR | 9.60 | |
| DST | Detroit Lions DST | 11.00 | 100% |
| Total | 113.4 | 88.5% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Brees QB | 14.00 | 100% |
| RB | Mark Ingram RB | 31.10 | 100% |
| RB | Tevin Coleman RB | 15.30 | |
| WR | Robby Anderson WR | 16.50 | 43.3% |
| WR | Martavis Bryant WR | 6.80 | |
| TE | Delanie Walker TE | 9.30 | 100% |
| FLEX | Rex Burkhead RB | 13.80 | 103.4% |
| FLEX | Matt Breida RB | 12.30 | |
| DST | Los Angeles Chargers DST | 8.00 | 62.5% |
| Total | 127.1 | 88% | |