| Starters | ||
| Pos | Player | Points |
| QB | Cam Newton QB | 35.70 |
| RB | Todd Gurley RB | 16.60 |
| RB | Chris Thompson RB | 10.80 |
| WR | Keenan Allen WR | 7.40 |
| WR | Stefon Diggs WR | 15.80 |
| TE | Hunter Henry TE | 1.20 |
| FLEX | Orleans Darkwa RB | 11.80 |
| FLEX | Cooper Kupp WR | 7.70 |
| DST | New York Giants DST | -2.00 |
| Total | 105 | |
| Starters | ||
| Pos | Player | Points |
| QB | Andy Dalton QB | 14.60 |
| RB | Ameer Abdullah RB | 12.00 |
| RB | Marlon Mack RB | 3.60 |
| WR | Michael Thomas WR | 16.20 |
| WR | Jamison Crowder WR | 10.10 |
| TE | Austin Seferian-Jenkins TE | 9.70 |
| FLEX | Corey Davis WR | 4.80 |
| FLEX | DOnta Foreman RB | 1.80 |
| DST | Carolina Panthers DST | 2.00 |
| Total | 74.8 | |
| Bench | ||
| Pos | Player | Points |
| BN | Sam Bradford QB | 0.00 |
| BN | Jeremy Hill RB | 0.00 |
| BN | C.J. Prosise RB | 0.30 |
| BN | Jalen Richard RB | 0.00 |
| BN | Josh Doctson WR | 5.00 |
| BN | Nelson Agholor WR | 0.00 |
| BN | New Orleans Saints DST | 10.00 |
| BN | Jared Cook TE | 0.00 |
| BN | Rod Smith RB | 4.90 |
| BN | Malcolm Brown RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Jameis Winston QB | 0.00 |
| BN | Alshon Jeffery WR | 0.00 |
| BN | Zay Jones WR | 0.00 |
| BN | Javorius Allen RB | 0.00 |
| BN | Denver Broncos DST | -3.00 |
| BN | Jake Butt TE | 0.00 |
| BN | Jeremy Maclin WR | 0.00 |
| BN | Jonnu Smith TE | 3.00 |
| BN | Josh Gordon WR | 0.00 |
| BN | Jimmy Garoppolo QB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Cam Newton QB | 35.70 | 100% |
| RB | Todd Gurley RB | 16.60 | 96.5% |
| RB | Orleans Darkwa RB | 11.80 | |
| WR | Stefon Diggs WR | 15.80 | 98.7% |
| WR | Cooper Kupp WR | 7.70 | |
| TE | Hunter Henry TE | 1.20 | 100% |
| FLEX | Chris Thompson RB | 10.80 | 107.1% |
| FLEX | Keenan Allen WR | 7.40 | |
| DST | New Orleans Saints DST | 10.00 | -20% |
| Total | 117 | 89.7% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Andy Dalton QB | 14.60 | 100% |
| RB | Ameer Abdullah RB | 12.00 | 100% |
| RB | Marlon Mack RB | 3.60 | |
| WR | Michael Thomas WR | 16.20 | 100% |
| WR | Jamison Crowder WR | 10.10 | |
| TE | Austin Seferian-Jenkins TE | 9.70 | 100% |
| FLEX | Corey Davis WR | 4.80 | 84.6% |
| FLEX | Jonnu Smith TE | 3.00 | |
| DST | Carolina Panthers DST | 2.00 | 100% |
| Total | 76 | 98.4% | |