| Starters | ||
| Pos | Player | Points |
| QB | Kyler Murray QB | 27.24 |
| RB | Aaron Jones RB | 17.40 |
| RB | Michael Carter RB | 4.60 |
| WR | Nelson Agholor WR | 15.50 |
| WR | Josh Reynolds WR | 0.00 |
| WR | Christian Kirk WR | 6.10 |
| TE | Cole Kmet TE | 4.20 |
| FLEX | Kenneth Walker RB | 16.40 |
| FLEX | Dameon Pierce RB | 3.10 |
| DST | New England Patriots DST | 1.00 |
| Total | 95.54 | |
| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 34.76 |
| RB | Dalvin Cook RB | 7.60 |
| RB | DAndre Swift RB | 8.30 |
| WR | Tyler Boyd WR | 2.60 |
| WR | Tyler Lockett WR | 14.30 |
| WR | JuJu Smith-Schuster WR | 5.30 |
| TE | Kyle Pitts TE | 0.00 |
| FLEX | Brandin Cooks WR | 8.60 |
| FLEX | Rachaad White RB | 15.40 |
| DST | New York Jets DST | 9.00 |
| Total | 105.86 | |
| Bench | ||
| Pos | Player | Points |
| BN | Josh Gordon WR | 0.00 |
| BN | Odell Beckham WR | 0.00 |
| BN | Jameis Winston QB | 0.00 |
| BN | Kansas City Chiefs DST | 13.00 |
| BN | Jared Goff QB | 21.60 |
| BN | O.J. Howard TE | 0.00 |
| BN | Jonnu Smith TE | 0.00 |
| BN | Sony Michel RB | 0.00 |
| BN | K.J. Hamler WR | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Denver Broncos DST | 2.00 |
| BN | Melvin Gordon RB | 0.00 |
| BN | Kenyan Drake RB | 0.20 |
| BN | Sammy Watkins WR | 0.00 |
| BN | Jerry Jeudy WR | 0.00 |
| BN | Clyde Edwards-Helaire RB | 0.00 |
| BN | Zach Wilson QB | 0.00 |
| BN | David Bell WR | 4.30 |
| BN | Isaiah Spiller RB | 1.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kyler Murray QB | 27.24 | 100% |
| RB | Aaron Jones RB | 17.40 | 65.1% |
| RB | Kenneth Walker RB | 16.40 | |
| WR | Nelson Agholor WR | 15.50 | 100% |
| WR | Christian Kirk WR | 6.10 | |
| TE | Cole Kmet TE | 4.20 | 100% |
| FLEX | Michael Carter RB | 4.60 | 253.2% |
| FLEX | Dameon Pierce RB | 3.10 | |
| DST | Kansas City Chiefs DST | 13.00 | 7.7% |
| Total | 107.54 | 88.8% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 34.76 | 100% |
| RB | Rachaad White RB | 15.40 | 67.1% |
| RB | DAndre Swift RB | 8.30 | |
| WR | Tyler Lockett WR | 14.30 | 77.6% |
| WR | Mack Hollins WR | 14.30 | |
| TE | Kyle Pitts TE | 0.00 | -- |
| FLEX | Brandin Cooks WR | 8.60 | 148.1% |
| FLEX | Dalvin Cook RB | 7.60 | |
| DST | New York Jets DST | 9.00 | 100% |
| Total | 112.26 | 94.3% | |