| Starters | ||
| Pos | Player | Points |
| QB | Mac Jones QB | 27.28 |
| RB | Mark Ingram RB | 1.00 |
| RB | Josh Jacobs RB | 45.30 |
| WR | D.K. Metcalf WR | 14.50 |
| WR | Donovan Peoples-Jones WR | 6.35 |
| WR | Brandon Aiyuk WR | 9.00 |
| TE | T.J. Hockenson TE | 12.80 |
| FLEX | Diontae Johnson WR | 7.40 |
| FLEX | CeeDee Lamb WR | 14.70 |
| DST | Minnesota Vikings DST | 6.00 |
| Total | 144.33 | |
| Starters | ||
| Pos | Player | Points |
| QB | Russell Wilson QB | 10.48 |
| RB | David Montgomery RB | 12.80 |
| RB | Jonathan Taylor RB | 17.30 |
| WR | Tee Higgins WR | 20.90 |
| WR | Justin Jefferson WR | 24.84 |
| WR | DeVonta Smith WR | 7.00 |
| TE | Pat Freiermuth TE | 5.40 |
| FLEX | Cordarrelle Patterson RB | 9.05 |
| FLEX | Travis Etienne RB | 0.30 |
| DST | San Francisco 49ers DST | 12.00 |
| Total | 120.07 | |
| Bench | ||
| Pos | Player | Points |
| BN | Matthew Stafford QB | 0.00 |
| BN | Kenny Golladay WR | 0.00 |
| BN | Tennessee Titans DST | 0.00 |
| BN | Irv Smith Jr. TE | 0.00 |
| BN | Darrell Henderson RB | 0.00 |
| BN | Eno Benjamin RB | 0.00 |
| BN | Alec Pierce WR | 0.00 |
| BN | Pierre Strong RB | 0.00 |
| BN | Zamir White RB | 2.80 |
| Bench | ||
| Pos | Player | Points |
| BN | Robert Woods WR | 2.60 |
| BN | Hunter Henry TE | 13.80 |
| BN | Green Bay Packers DST | -5.00 |
| BN | Braxton Berrios WR | 3.70 |
| BN | Hollywood Brown WR | 7.60 |
| BN | Justin Fields QB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Mac Jones QB | 27.28 | 100% |
| RB | Josh Jacobs RB | 45.30 | 77.7% |
| RB | Kene Nwangwu RB | 14.30 | |
| WR | Christian Watson WR | 19.00 | 88.6% |
| WR | CeeDee Lamb WR | 14.70 | |
| TE | T.J. Hockenson TE | 12.80 | 100% |
| FLEX | D.K. Metcalf WR | 14.50 | 94% |
| FLEX | Brandon Aiyuk WR | 9.00 | |
| DST | Minnesota Vikings DST | 6.00 | 100% |
| Total | 162.88 | 88.6% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Russell Wilson QB | 10.48 | 100% |
| RB | Jonathan Taylor RB | 17.30 | 100% |
| RB | David Montgomery RB | 12.80 | |
| WR | Justin Jefferson WR | 24.84 | 115.3% |
| WR | Tee Higgins WR | 20.90 | |
| TE | Hunter Henry TE | 13.80 | 39.1% |
| FLEX | Cordarrelle Patterson RB | 9.05 | 53% |
| FLEX | DJ Chark Jr. WR | 8.60 | |
| DST | San Francisco 49ers DST | 12.00 | 100% |
| Total | 129.77 | 92.5% | |