| Starters | ||
| Pos | Player | Points |
| QB | Josh Allen QB | 22.58 |
| RB | Christian McCaffrey RB | 28.30 |
| RB | Joe Mixon RB | 11.60 |
| WR | Amari Cooper WR | 5.20 |
| WR | Davante Adams WR | 8.60 |
| WR | Keenan Allen WR | 15.20 |
| TE | Dalton Schultz TE | 11.70 |
| FLEX | DeAndre Hopkins WR | 9.40 |
| FLEX | Mike Evans WR | 6.40 |
| DST | Tampa Bay Buccaneers DST | -4.00 |
| Total | 114.98 | |
| Starters | ||
| Pos | Player | Points |
| QB | Geno Smith QB | 22.56 |
| RB | Derrick Henry RB | 19.00 |
| RB | Cam Akers RB | 8.80 |
| WR | Devin Duvernay WR | 1.40 |
| WR | Amon-Ra St. Brown WR | 10.40 |
| WR | Garrett Wilson WR | 10.80 |
| TE | Travis Kelce TE | 9.10 |
| FLEX | Jamaal Williams RB | 3.70 |
| FLEX | Austin Ekeler RB | 20.40 |
| DST | Seattle Seahawks DST | 1.00 |
| Total | 107.16 | |
| Bench | ||
| Pos | Player | Points |
| BN | Washington Commanders DST | 0.00 |
| BN | Cincinnati Bengals DST | 7.00 |
| BN | Tyler Higbee TE | 2.10 |
| BN | Leonard Fournette RB | 7.60 |
| BN | DOnta Foreman RB | 8.00 |
| BN | Curtis Samuel WR | 0.00 |
| BN | Adam Thielen WR | 16.00 |
| BN | Raheem Mostert RB | 4.90 |
| BN | Antonio Gibson RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Arizona Cardinals DST | 3.00 |
| BN | Ryan Tannehill QB | 19.76 |
| BN | Dallas Goedert TE | 0.00 |
| BN | Allen Lazard WR | 0.00 |
| BN | Taysom Hill TE | 0.00 |
| BN | Mecole Hardman WR | 0.00 |
| BN | Van Jefferson WR | 11.40 |
| BN | Skyy Moore WR | 1.20 |
| BN | Brian Robinson RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kirk Cousins QB | 29.00 | 77.9% |
| RB | Christian McCaffrey RB | 28.30 | 100% |
| RB | Joe Mixon RB | 11.60 | |
| WR | Adam Thielen WR | 16.00 | 92.9% |
| WR | Keenan Allen WR | 15.20 | |
| TE | Dalton Schultz TE | 11.70 | 100% |
| FLEX | DeAndre Hopkins WR | 9.40 | 87.8% |
| FLEX | Davante Adams WR | 8.60 | |
| DST | Cincinnati Bengals DST | 7.00 | -57.1% |
| Total | 136.8 | 84% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Geno Smith QB | 22.56 | 100% |
| RB | Austin Ekeler RB | 20.40 | 70.6% |
| RB | Derrick Henry RB | 19.00 | |
| WR | Van Jefferson WR | 11.40 | 101.8% |
| WR | Garrett Wilson WR | 10.80 | |
| TE | Travis Kelce TE | 9.10 | 100% |
| FLEX | Amon-Ra St. Brown WR | 10.40 | 124.2% |
| FLEX | Jamal Agnew WR | 9.00 | |
| DST | Arizona Cardinals DST | 3.00 | 33.3% |
| Total | 115.66 | 92.7% | |