| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 3.50 |
| RB | Dalvin Cook RB | 9.20 |
| RB | DAndre Swift RB | 3.00 |
| WR | Brandin Cooks WR | 11.40 |
| WR | JuJu Smith-Schuster WR | 4.20 |
| WR | Jerry Jeudy WR | 14.70 |
| TE | Tyler Conklin TE | 5.40 |
| FLEX | Tyler Boyd WR | 3.60 |
| FLEX | Rachaad White RB | 13.30 |
| DST | Denver Broncos DST | -4.00 |
| Total | 64.3 | |
| Starters | ||
| Pos | Player | Points |
| QB | Josh Allen QB | 22.98 |
| RB | Christian McCaffrey RB | 12.80 |
| RB | Joe Mixon RB | 14.30 |
| WR | DeAndre Hopkins WR | 0.90 |
| WR | Davante Adams WR | 2.50 |
| WR | Keenan Allen WR | 15.90 |
| TE | Dalton Schultz TE | 5.80 |
| FLEX | Mike Evans WR | 4.40 |
| FLEX | Raheem Mostert RB | 9.60 |
| DST | Tampa Bay Buccaneers DST | 8.00 |
| Total | 97.18 | |
| Bench | ||
| Pos | Player | Points |
| BN | Melvin Gordon RB | 0.00 |
| BN | Tyler Lockett WR | 0.00 |
| BN | Kenyan Drake RB | 0.00 |
| BN | New York Jets DST | 2.00 |
| BN | Clyde Edwards-Helaire RB | 0.00 |
| BN | Kyle Pitts TE | 0.00 |
| BN | Zach Wilson QB | -0.22 |
| BN | David Bell WR | 2.30 |
| BN | Isaiah Spiller RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Amari Cooper WR | 10.20 |
| BN | Washington Commanders DST | 1.00 |
| BN | Cincinnati Bengals DST | 11.00 |
| BN | Tyler Higbee TE | 26.25 |
| BN | Leonard Fournette RB | 20.70 |
| BN | DOnta Foreman RB | 22.50 |
| BN | Adam Thielen WR | 1.10 |
| BN | Zack Moss RB | 7.50 |
| BN | Antonio Gibson RB | 6.05 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Desmond Ridder QB | 9.52 | 36.8% |
| RB | Rachaad White RB | 13.30 | 54.2% |
| RB | Dalvin Cook RB | 9.20 | |
| WR | Jerry Jeudy WR | 14.70 | 116.1% |
| WR | Brandin Cooks WR | 11.40 | |
| TE | Tyler Conklin TE | 5.40 | 100% |
| FLEX | Sammy Watkins WR | 4.50 | 194.3% |
| FLEX | JuJu Smith-Schuster WR | 4.20 | |
| DST | New York Jets DST | 2.00 | -200% |
| Total | 74.22 | 86.6% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kirk Cousins QB | 30.16 | 76.2% |
| RB | DOnta Foreman RB | 22.50 | 62.7% |
| RB | Leonard Fournette RB | 20.70 | |
| WR | Keenan Allen WR | 15.90 | 73.9% |
| WR | Amari Cooper WR | 10.20 | |
| TE | Tyler Higbee TE | 26.25 | 22.1% |
| FLEX | Joe Mixon RB | 14.30 | 51.7% |
| FLEX | Christian McCaffrey RB | 12.80 | |
| DST | Cincinnati Bengals DST | 11.00 | 72.7% |
| Total | 163.81 | 59.3% | |