| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 20.68 |
| RB | Dalvin Cook RB | 5.40 |
| RB | DAndre Swift RB | 25.70 |
| WR | Tyler Lockett WR | 2.50 |
| WR | Brandin Cooks WR | 5.90 |
| WR | Jerry Jeudy WR | 7.30 |
| TE | Tyler Conklin TE | 11.00 |
| FLEX | JuJu Smith-Schuster WR | 3.10 |
| FLEX | Rachaad White RB | 7.30 |
| DST | New York Jets DST | 4.00 |
| Total | 92.88 | |
| Starters | ||
| Pos | Player | Points |
| QB | Josh Allen QB | 0.00 |
| RB | Christian McCaffrey RB | 28.30 |
| RB | Joe Mixon RB | 0.00 |
| WR | Amari Cooper WR | 24.00 |
| WR | Davante Adams WR | 30.80 |
| WR | Keenan Allen WR | 9.30 |
| TE | Tyler Higbee TE | 2.60 |
| FLEX | Mike Evans WR | 43.70 |
| FLEX | Leonard Fournette RB | 6.70 |
| DST | Tampa Bay Buccaneers DST | 5.00 |
| Total | 150.4 | |
| Bench | ||
| Pos | Player | Points |
| BN | Denver Broncos DST | 5.00 |
| BN | Melvin Gordon RB | 0.00 |
| BN | Tyler Boyd WR | 0.00 |
| BN | Kenyan Drake RB | 0.00 |
| BN | Clyde Edwards-Helaire RB | 0.00 |
| BN | Kyle Pitts TE | 0.00 |
| BN | Zach Wilson QB | 0.00 |
| BN | David Bell WR | 0.00 |
| BN | Isaiah Spiller RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | DeAndre Hopkins WR | 0.00 |
| BN | Washington Commanders DST | 5.00 |
| BN | Cincinnati Bengals DST | 0.00 |
| BN | DOnta Foreman RB | 3.50 |
| BN | Curtis Samuel WR | 1.10 |
| BN | Adam Thielen WR | 2.10 |
| BN | Raheem Mostert RB | 23.05 |
| BN | Dalton Schultz TE | 21.10 |
| BN | Antonio Gibson RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 20.68 | 100% |
| RB | DAndre Swift RB | 25.70 | 94.2% |
| RB | Rachaad White RB | 7.30 | |
| WR | Jerry Jeudy WR | 7.30 | 118.9% |
| WR | Brandin Cooks WR | 5.90 | |
| TE | Tyler Conklin TE | 11.00 | 100% |
| FLEX | Mack Hollins WR | 5.50 | 95.4% |
| FLEX | Dalvin Cook RB | 5.40 | |
| DST | Denver Broncos DST | 5.00 | 80% |
| Total | 93.78 | 99% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Josh Allen QB | 0.00 | 0% |
| RB | Christian McCaffrey RB | 28.30 | 55.1% |
| RB | Raheem Mostert RB | 23.05 | |
| WR | Mike Evans WR | 43.70 | 86% |
| WR | Davante Adams WR | 30.80 | |
| TE | Dalton Schultz TE | 21.10 | 12.3% |
| FLEX | Amari Cooper WR | 24.00 | 151.4% |
| FLEX | Keenan Allen WR | 9.30 | |
| DST | Washington Commanders DST | 5.00 | 100% |
| Total | 185.25 | 81.2% | |