| Starters | ||
| Pos | Player | Points |
| QB | Marcus Mariota QB | 17.70 |
| RB | Latavius Murray RB | 12.80 |
| RB | Jerick McKinnon RB | 5.70 |
| WR | Kelvin Benjamin WR | 5.70 |
| WR | Randall Cobb WR | 7.50 |
| TE | Ed Dickson TE | 10.80 |
| FLEX | Dion Lewis RB | 22.70 |
| FLEX | Evan Engram TE | 12.10 |
| DST | Pittsburgh Steelers DST | 8.00 |
| Total | 103 | |
| Starters | ||
| Pos | Player | Points |
| QB | Terrance Williams QB | 0.00 |
| RB | Storm Johnson RB | 0.00 |
| RB | Brian Hill RB | 0.00 |
| WR | Julian Edelman WR | 0.00 |
| WR | Davante Adams WR | 17.50 |
| TE | Fred Davis TE | 0.00 |
| FLEX | Adam Shaheen TE | 4.90 |
| FLEX | Clark Harris TE | 0.00 |
| DST | Tampa Bay Buccaneers DST | 15.00 |
| Total | 37.4 | |
| Bench | ||
| Pos | Player | Points |
| BN | Carson Palmer QB | 0.00 |
| BN | Chris Hogan WR | 0.00 |
| BN | Pierre Garcon WR | 0.00 |
| BN | Arizona Cardinals DST | 7.00 |
| BN | Charcandrick West RB | 0.00 |
| BN | Tyrell Williams WR | 5.90 |
| BN | Kerwynn Williams RB | 3.10 |
| BN | Josh McCown QB | 12.50 |
| BN | Eddie Lacy RB | 0.00 |
| BN | Terrance Williams WR | 1.40 |
| Bench | ||
| Pos | Player | Points |
| BN | Christian McCaffrey RB | 19.00 |
| BN | DeMarco Murray RB | 27.20 |
| BN | Jay Ajayi RB | 0.00 |
| BN | Brandin Cooks WR | 10.40 |
| BN | Emmanuel Sanders WR | 16.70 |
| BN | Marvin Jones WR | 2.70 |
| BN | Zach Ertz TE | 0.00 |
| BN | Baltimore Ravens DST | 0.00 |
| BN | Aaron Jones RB | 1.70 |
| BN | T.Y. Hilton WR | 3.30 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Marcus Mariota QB | 17.70 | 100% |
| RB | Dion Lewis RB | 22.70 | 52.1% |
| RB | Latavius Murray RB | 12.80 | |
| WR | Randall Cobb WR | 7.50 | 98.5% |
| WR | Tyrell Williams WR | 5.90 | |
| TE | Evan Engram TE | 12.10 | 89.3% |
| FLEX | Ed Dickson TE | 10.80 | 210.9% |
| FLEX | Jerick McKinnon RB | 5.70 | |
| DST | Pittsburgh Steelers DST | 8.00 | 100% |
| Total | 103.2 | 99.8% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| RB | DeMarco Murray RB | 27.20 | 0% |
| RB | Christian McCaffrey RB | 19.00 | |
| WR | Davante Adams WR | 17.50 | 51.2% |
| WR | Emmanuel Sanders WR | 16.70 | |
| TE | Adam Shaheen TE | 4.90 | 0% |
| FLEX | Brandin Cooks WR | 10.40 | 35.8% |
| FLEX | T.Y. Hilton WR | 3.30 | |
| DST | Tampa Bay Buccaneers DST | 15.00 | 100% |
| Total | 114 | 32.8% | |