| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 21.60 |
| RB | Mark Ingram RB | 23.00 |
| RB | Tevin Coleman RB | 12.30 |
| WR | Antonio Brown WR | 38.60 |
| WR | Michael Crabtree WR | 10.10 |
| TE | Delanie Walker TE | 12.20 |
| FLEX | Rex Burkhead RB | 5.70 |
| FLEX | Joe Mixon RB | 5.90 |
| DST | Los Angeles Chargers DST | 24.00 |
| Total | 153.4 | |
| Starters | ||
| Pos | Player | Points |
| QB | Ben Roethlisberger QB | 29.00 |
| RB | Devontae Booker RB | 12.30 |
| RB | Jordan Howard RB | 18.50 |
| WR | Tyler Lockett WR | 15.60 |
| WR | Jordan Matthews WR | 0.00 |
| TE | Travis Kelce TE | 12.90 |
| FLEX | Theo Riddick RB | 4.40 |
| FLEX | Cameron Brate TE | 1.70 |
| DST | Los Angeles Rams DST | -5.00 |
| Total | 89.4 | |
| Bench | ||
| Pos | Player | Points |
| BN | Will Fuller WR | 0.00 |
| BN | Martavis Bryant WR | 4.00 |
| BN | Jordy Nelson WR | 3.40 |
| BN | Terrelle Pryor WR | 0.00 |
| BN | Robby Anderson WR | 0.00 |
| BN | Deshaun Watson QB | 0.00 |
| BN | James Conner RB | 1.20 |
| BN | Damien Williams RB | 10.70 |
| BN | Matt Breida RB | 0.00 |
| BN | Tennessee Titans DST | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Philip Rivers QB | 18.00 |
| BN | Derrick Henry RB | 3.20 |
| BN | Carlos Hyde RB | 0.00 |
| BN | David Johnson RB | 0.00 |
| BN | Terrance West RB | 0.00 |
| BN | Odell Beckham WR | 0.00 |
| BN | Donte Moncrief WR | 0.00 |
| BN | Willie Snead WR | 2.60 |
| BN | Philadelphia Eagles DST | 23.00 |
| BN | Jay Cutler QB | 1.40 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Brees QB | 21.60 | 100% |
| RB | Mark Ingram RB | 23.00 | 100% |
| RB | Tevin Coleman RB | 12.30 | |
| WR | Antonio Brown WR | 38.60 | 100% |
| WR | Michael Crabtree WR | 10.10 | |
| TE | Delanie Walker TE | 12.20 | 100% |
| FLEX | Damien Williams RB | 10.70 | 69.9% |
| FLEX | Joe Mixon RB | 5.90 | |
| DST | Los Angeles Chargers DST | 24.00 | 100% |
| Total | 158.4 | 96.8% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Ben Roethlisberger QB | 29.00 | 100% |
| RB | Jordan Howard RB | 18.50 | 100% |
| RB | Devontae Booker RB | 12.30 | |
| WR | Tyler Lockett WR | 15.60 | 85.7% |
| WR | Willie Snead WR | 2.60 | |
| TE | Travis Kelce TE | 12.90 | 100% |
| FLEX | Theo Riddick RB | 4.40 | 80.3% |
| FLEX | Derrick Henry RB | 3.20 | |
| DST | Philadelphia Eagles DST | 23.00 | -21.7% |
| Total | 121.5 | 73.6% | |