| Starters | ||
| Pos | Player | Points |
| QB | Kyler Murray QB | 12.58 |
| RB | Dalvin Cook RB | 10.10 |
| RB | Michael Carter RB | 2.50 |
| WR | Mike Evans WR | 1.90 |
| WR | TreQuan Smith WR | 2.70 |
| TE | Jonnu Smith TE | 1.00 |
| FLEX | Sony Michel RB | 12.50 |
| FLEX | Christian Kirk WR | 19.90 |
| DST | Jacksonville Jaguars DST | 4.00 |
| Total | 67.18 | |
| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 25.04 |
| RB | Melvin Gordon RB | 6.60 |
| RB | Clyde Edwards-Helaire RB | 8.00 |
| WR | A.J. Green WR | 8.40 |
| WR | Brandin Cooks WR | 25.70 |
| TE | Kyle Pitts TE | 9.70 |
| FLEX | Tyler Boyd WR | 18.10 |
| FLEX | Jerry Jeudy WR | 0.00 |
| DST | Denver Broncos DST | 6.00 |
| Total | 107.54 | |
| Bench | ||
| Pos | Player | Points |
| BN | Tevin Coleman RB | 5.00 |
| BN | T.Y. Hilton WR | 2.40 |
| BN | Odell Beckham WR | 1.20 |
| BN | New England Patriots DST | 5.00 |
| BN | Ronald Jones II RB | 8.10 |
| BN | Benny Snell Jr. RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Sammy Watkins WR | 0.00 |
| BN | Robby Anderson WR | 7.70 |
| BN | Marlon Mack RB | 0.00 |
| BN | Derrius Guice RB | 0.00 |
| BN | Antonio Gandy-Golden TE | 0.00 |
| BN | Joshua Kelley RB | 0.10 |
| BN | Jalen Reagor WR | 8.30 |
| BN | Javian Hawkins RB | 0.00 |
| BN | Jermar Jefferson RB | 0.90 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Mac Jones QB | 17.16 | 73.3% |
| RB | Sony Michel RB | 12.50 | 55.8% |
| RB | Dalvin Cook RB | 10.10 | |
| WR | Christian Kirk WR | 19.90 | 20.4% |
| WR | TreQuan Smith WR | 2.70 | |
| TE | Hayden Hurst TE | 1.60 | 62.5% |
| FLEX | Ronald Jones II RB | 8.10 | 247.3% |
| FLEX | Tevin Coleman RB | 5.00 | |
| DST | New England Patriots DST | 5.00 | 80% |
| Total | 82.06 | 81.9% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jared Goff QB | 26.64 | 94% |
| RB | Clyde Edwards-Helaire RB | 8.00 | 100% |
| RB | Melvin Gordon RB | 6.60 | |
| WR | Brandin Cooks WR | 25.70 | 77.9% |
| WR | Tyler Boyd WR | 18.10 | |
| TE | Kyle Pitts TE | 9.70 | 100% |
| FLEX | A.J. Green WR | 8.40 | 108.4% |
| FLEX | Jalen Reagor WR | 8.30 | |
| DST | Denver Broncos DST | 6.00 | 100% |
| Total | 117.44 | 91.6% | |