| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 23.38 |
| RB | Dalvin Cook RB | 2.30 |
| RB | DAndre Swift RB | 15.90 |
| WR | Tyler Boyd WR | 4.60 |
| WR | Brandin Cooks WR | 4.70 |
| WR | Jerry Jeudy WR | 6.70 |
| TE | Kyle Pitts TE | 3.10 |
| FLEX | Rachaad White RB | 9.30 |
| FLEX | Breece Hall RB | 8.40 |
| DST | New York Jets DST | 4.00 |
| Total | 82.38 | |
| Starters | ||
| Pos | Player | Points |
| QB | Jared Goff QB | 11.40 |
| RB | Aaron Jones RB | 1.90 |
| RB | Kenneth Walker RB | 13.90 |
| WR | Deebo Samuel WR | 0.60 |
| WR | Rashid Shaheed WR | 9.00 |
| WR | Zay Flowers WR | 6.50 |
| TE | Tyler Higbee TE | 8.90 |
| FLEX | Josh Reynolds WR | 8.40 |
| FLEX | Dameon Pierce RB | 11.30 |
| DST | Kansas City Chiefs DST | 4.00 |
| Total | 75.9 | |
| Bench | ||
| Pos | Player | Points |
| BN | Kenyan Drake RB | 0.00 |
| BN | JuJu Smith-Schuster WR | 1.90 |
| BN | Tyler Conklin TE | 7.80 |
| BN | Desmond Ridder QB | 4.24 |
| BN | David Bell WR | 0.00 |
| BN | Isaiah Spiller RB | 3.70 |
| Bench | ||
| Pos | Player | Points |
| BN | Allen Robinson WR | 1.30 |
| BN | Nelson Agholor WR | 0.90 |
| BN | New England Patriots DST | 2.00 |
| BN | Samaje Perine RB | 4.50 |
| BN | Adam Thielen WR | 11.70 |
| BN | Christian Kirk WR | 13.00 |
| BN | Kyler Murray QB | 0.00 |
| BN | Cole Kmet TE | 24.10 |
| BN | Bryce Young QB | 7.16 |
| BN | Jalin Hyatt WR | 2.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 23.38 | 100% |
| RB | DAndre Swift RB | 15.90 | 72.2% |
| RB | Rachaad White RB | 9.30 | |
| WR | Jerry Jeudy WR | 6.70 | 140.4% |
| WR | Brandin Cooks WR | 4.70 | |
| TE | Tyler Conklin TE | 7.80 | 39.7% |
| FLEX | Breece Hall RB | 8.40 | 136.2% |
| FLEX | Tyler Boyd WR | 4.60 | |
| DST | New York Jets DST | 4.00 | 100% |
| Total | 84.78 | 97.2% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jared Goff QB | 11.40 | 100% |
| RB | Kenneth Walker RB | 13.90 | 62.7% |
| RB | Dameon Pierce RB | 11.30 | |
| WR | Christian Kirk WR | 13.00 | 65.2% |
| WR | Adam Thielen WR | 11.70 | |
| TE | Cole Kmet TE | 24.10 | 36.9% |
| FLEX | Jayden Reed WR | 9.00 | 109.4% |
| FLEX | Rashid Shaheed WR | 9.00 | |
| DST | Kansas City Chiefs DST | 4.00 | 100% |
| Total | 107.4 | 70.7% | |