| Starters | ||
| Pos | Player | Points |
| QB | Jalen Hurts QB | 15.90 |
| RB | Gus Edwards RB | 5.80 |
| RB | Emari Demercado RB | 2.20 |
| WR | Cooper Kupp WR | 24.30 |
| WR | Calvin Ridley WR | 4.60 |
| WR | Michael Pittman Jr. WR | 15.40 |
| TE | Mark Andrews TE | 8.90 |
| FLEX | Braxton Berrios WR | 3.00 |
| FLEX | Sam LaPorta TE | 5.60 |
| DST | Buffalo Bills DST | 6.00 |
| Total | 91.7 | |
| Starters | ||
| Pos | Player | Points |
| QB | Geno Smith QB | 6.92 |
| RB | Derrick Henry RB | 18.30 |
| RB | Brian Robinson RB | 12.60 |
| WR | DeAndre Hopkins WR | 2.50 |
| WR | Amon-Ra St. Brown WR | 24.40 |
| WR | Garrett Wilson WR | 13.00 |
| TE | Dallas Goedert TE | 6.70 |
| FLEX | Austin Ekeler RB | 8.20 |
| FLEX | Jakobi Meyers WR | 14.60 |
| DST | Seattle Seahawks DST | 8.00 |
| Total | 115.22 | |
| Bench | ||
| Pos | Player | Points |
| BN | Detroit Lions DST | 9.00 |
| BN | David Njoku TE | 3.90 |
| BN | New Orleans Saints DST | 6.00 |
| BN | Jeff Wilson Jr. RB | 0.00 |
| BN | Miles Sanders RB | 0.00 |
| BN | Van Jefferson WR | 0.00 |
| BN | Kenneth Gainwell RB | 2.20 |
| BN | Brock Purdy QB | 7.70 |
| BN | Justyn Ross WR | 0.00 |
| BN | Deuce Vaughn RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Russell Wilson QB | 4.90 |
| BN | Tampa Bay Buccaneers DST | 2.00 |
| BN | Matt Breida RB | 1.30 |
| BN | Brandon Powell WR | 5.00 |
| BN | Joshua Kelley RB | 0.90 |
| BN | Rico Dowdle RB | 1.20 |
| BN | Cam Akers RB | 2.00 |
| BN | Skyy Moore WR | 3.20 |
| BN | Jonathan Mingo WR | 3.10 |
| BN | Kendre Miller RB | 1.70 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jalen Hurts QB | 15.90 | 100% |
| RB | Ezekiel Elliott RB | 11.40 | 46.5% |
| RB | Gus Edwards RB | 5.80 | |
| WR | Cooper Kupp WR | 24.30 | 111.6% |
| WR | Michael Pittman Jr. WR | 15.40 | |
| TE | Mark Andrews TE | 8.90 | 100% |
| FLEX | Jordan Addison WR | 10.30 | 50.3% |
| FLEX | Jaxon Smith-Njigba WR | 6.80 | |
| DST | Detroit Lions DST | 9.00 | 66.7% |
| Total | 107.8 | 85.1% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Geno Smith QB | 6.92 | 100% |
| RB | Derrick Henry RB | 18.30 | 100% |
| RB | Brian Robinson RB | 12.60 | |
| WR | Amon-Ra St. Brown WR | 24.40 | 102.3% |
| WR | Jakobi Meyers WR | 14.60 | |
| TE | Taysom Hill TE | 8.76 | 76.5% |
| FLEX | Garrett Wilson WR | 13.00 | 107.5% |
| FLEX | Austin Ekeler RB | 8.20 | |
| DST | Seattle Seahawks DST | 8.00 | 100% |
| Total | 114.78 | 100.4% | |