| Starters | ||
| Pos | Player | Points |
| QB | Kirk Cousins QB | 26.00 |
| RB | Marshawn Lynch RB | 8.20 |
| RB | Samaje Perine RB | 19.10 |
| WR | Jarvis Landry WR | 17.30 |
| WR | Golden Tate WR | 4.70 |
| TE | Tyler Kroft TE | 8.20 |
| FLEX | DeVante Parker WR | 4.60 |
| FLEX | DeSean Jackson WR | 9.80 |
| DST | Detroit Lions DST | 8.00 |
| Total | 105.9 | |
| Starters | ||
| Pos | Player | Points |
| QB | Marcus Mariota QB | 14.70 |
| RB | Jerick McKinnon RB | 8.50 |
| RB | Latavius Murray RB | 22.10 |
| WR | Randall Cobb WR | 4.90 |
| WR | Kelvin Benjamin WR | 2.50 |
| TE | Evan Engram TE | 1.40 |
| FLEX | Dion Lewis RB | 16.80 |
| FLEX | Tyrell Williams WR | 1.60 |
| DST | Arizona Cardinals DST | 3.00 |
| Total | 75.5 | |
| Bench | ||
| Pos | Player | Points |
| BN | Taylor Gabriel WR | 1.70 |
| BN | Alex Smith QB | 7.90 |
| BN | LeGarrette Blount RB | 5.70 |
| BN | Frank Gore RB | 0.00 |
| BN | Ty Montgomery RB | 0.00 |
| BN | Bilal Powell RB | 0.00 |
| BN | Kansas City Chiefs DST | 5.00 |
| BN | George Kittle TE | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Pittsburgh Steelers DST | 16.00 |
| BN | Pierre Garcon WR | 0.00 |
| BN | Charcandrick West RB | 4.40 |
| BN | Eddie Lacy RB | 0.20 |
| BN | Carson Palmer QB | 0.00 |
| BN | Ed Dickson TE | 0.00 |
| BN | Chris Hogan WR | 0.00 |
| BN | Josh McCown QB | 0.00 |
| BN | Kerwynn Williams RB | 4.40 |
| BN | Terrance Williams WR | 5.50 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kirk Cousins QB | 26.00 | 100% |
| RB | Samaje Perine RB | 19.10 | 100% |
| RB | Marshawn Lynch RB | 8.20 | |
| WR | Jarvis Landry WR | 17.30 | 81.2% |
| WR | DeSean Jackson WR | 9.80 | |
| TE | Tyler Kroft TE | 8.20 | 100% |
| FLEX | LeGarrette Blount RB | 5.70 | 138.5% |
| FLEX | Golden Tate WR | 4.70 | |
| DST | Detroit Lions DST | 8.00 | 100% |
| Total | 107 | 99% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Marcus Mariota QB | 14.70 | 100% |
| RB | Latavius Murray RB | 22.10 | 78.7% |
| RB | Dion Lewis RB | 16.80 | |
| WR | Terrance Williams WR | 5.50 | 71.2% |
| WR | Randall Cobb WR | 4.90 | |
| TE | Evan Engram TE | 1.40 | 100% |
| FLEX | Jerick McKinnon RB | 8.50 | 142.6% |
| FLEX | Charcandrick West RB | 4.40 | |
| DST | Pittsburgh Steelers DST | 16.00 | 18.8% |
| Total | 94.3 | 80.1% | |