| Starters | ||
| Pos | Player | Points |
| QB | Jordan Love QB | 17.30 |
| RB | Kareem Hunt RB | 15.10 |
| RB | Saquon Barkley RB | 17.30 |
| WR | Keenan Allen WR | 7.50 |
| WR | Courtland Sutton WR | 16.60 |
| WR | A.J. Brown WR | 24.70 |
| TE | George Kittle TE | 10.50 |
| FLEX | George Pickens WR | 13.20 |
| FLEX | Romeo Doubs WR | 10.00 |
| DST | Baltimore Ravens DST | 11.00 |
| Total | 143.2 | |
| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 8.86 |
| RB | DAndre Swift RB | 9.00 |
| RB | Rachaad White RB | 12.90 |
| WR | JuJu Smith-Schuster WR | 0.00 |
| WR | Jerry Jeudy WR | 8.90 |
| WR | David Bell WR | 0.00 |
| TE | Kyle Pitts TE | 6.20 |
| FLEX | Matt Breida RB | 1.40 |
| FLEX | Isaiah Spiller RB | 0.00 |
| DST | Los Angeles Rams DST | 2.00 |
| Total | 49.26 | |
| Bench | ||
| Pos | Player | Points |
| BN | Los Angeles Chargers DST | -1.00 |
| BN | Zach Ertz TE | 3.40 |
| BN | Joshua Dobbs QB | 16.14 |
| BN | Daniel Jones QB | 0.00 |
| BN | Irv Smith Jr. TE | 0.00 |
| BN | Rashod Bateman WR | 4.60 |
| BN | Tutu Atwell WR | 9.60 |
| BN | Khalil Herbert RB | 0.00 |
| BN | Tyler Allgeier RB | 12.70 |
| BN | Tank Dell WR | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Tyler Boyd WR | 0.00 |
| BN | Kenyan Drake RB | 0.00 |
| BN | New York Jets DST | 0.00 |
| BN | Brandin Cooks WR | 0.00 |
| BN | Dalvin Cook RB | 0.00 |
| BN | Tyler Conklin TE | 0.00 |
| BN | Desmond Ridder QB | 13.80 |
| BN | Breece Hall RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jordan Love QB | 17.30 | 100% |
| RB | Saquon Barkley RB | 17.30 | 100% |
| RB | Kareem Hunt RB | 15.10 | |
| WR | A.J. Brown WR | 24.70 | 118.2% |
| WR | Courtland Sutton WR | 16.60 | |
| TE | George Kittle TE | 10.50 | 100% |
| FLEX | George Pickens WR | 13.20 | 89.6% |
| FLEX | Tyler Allgeier RB | 12.70 | |
| DST | Baltimore Ravens DST | 11.00 | 100% |
| Total | 138.4 | 103.5% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Desmond Ridder QB | 13.80 | 64.2% |
| RB | Rachaad White RB | 12.90 | 100% |
| RB | DAndre Swift RB | 9.00 | |
| WR | Jerry Jeudy WR | 8.90 | 100% |
| WR | Kayshon Boutte WR | 0.00 | |
| TE | Kyle Pitts TE | 6.20 | 100% |
| FLEX | Chris Rodriguez RB | 3.10 | 31.1% |
| FLEX | Matt Breida RB | 1.40 | |
| DST | Los Angeles Rams DST | 2.00 | 100% |
| Total | 57.3 | 86% | |