| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 30.02 |
| RB | DAndre Swift RB | 13.40 |
| RB | Rachaad White RB | 14.40 |
| WR | Tyler Boyd WR | 12.10 |
| WR | Brandin Cooks WR | 12.70 |
| WR | Jerry Jeudy WR | 12.00 |
| TE | Kyle Pitts TE | 5.00 |
| FLEX | JuJu Smith-Schuster WR | 6.80 |
| FLEX | Breece Hall RB | 18.30 |
| DST | New York Jets DST | 10.00 |
| Total | 134.72 | |
| Starters | ||
| Pos | Player | Points |
| QB | Matthew Stafford QB | 11.38 |
| RB | Alexander Mattison RB | 3.80 |
| RB | Jonathan Taylor RB | 10.20 |
| WR | Tyler Lockett WR | 18.10 |
| WR | DJ Chark Jr. WR | 3.30 |
| WR | DeVonta Smith WR | 19.40 |
| TE | Jonnu Smith TE | 1.80 |
| FLEX | Craig Reynolds RB | 7.10 |
| FLEX | Tee Higgins WR | 9.40 |
| DST | San Francisco 49ers DST | 1.00 |
| Total | 85.48 | |
| Bench | ||
| Pos | Player | Points |
| BN | Kenyan Drake RB | 0.00 |
| BN | Los Angeles Rams DST | 1.00 |
| BN | Dalvin Cook RB | 0.50 |
| BN | Matt Breida RB | 2.20 |
| BN | Tyler Conklin TE | 0.00 |
| BN | Desmond Ridder QB | 3.44 |
| BN | David Bell WR | 0.00 |
| BN | Isaiah Spiller RB | 1.30 |
| Bench | ||
| Pos | Player | Points |
| BN | Pittsburgh Steelers DST | 8.00 |
| BN | Jerick McKinnon RB | 1.40 |
| BN | Jamaal Williams RB | 4.30 |
| BN | Baker Mayfield QB | 25.38 |
| BN | Marquez Valdes-Scantling WR | 1.70 |
| BN | Dawson Knox TE | 0.00 |
| BN | Pat Freiermuth TE | 0.00 |
| BN | Justin Fields QB | 0.00 |
| BN | Deon Jackson RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 30.02 | 100% |
| RB | Breece Hall RB | 18.30 | 85% |
| RB | Rachaad White RB | 14.40 | |
| WR | Brandin Cooks WR | 12.70 | 148.4% |
| WR | Tyler Boyd WR | 12.10 | |
| TE | Kyle Pitts TE | 5.00 | 100% |
| FLEX | DAndre Swift RB | 13.40 | 98.8% |
| FLEX | Jerry Jeudy WR | 12.00 | |
| DST | New York Jets DST | 10.00 | 100% |
| Total | 127.92 | 105.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Baker Mayfield QB | 25.38 | 44.8% |
| RB | Jonathan Taylor RB | 10.20 | 80.9% |
| RB | Craig Reynolds RB | 7.10 | |
| WR | DeVonta Smith WR | 19.40 | 108.8% |
| WR | Tyler Lockett WR | 18.10 | |
| TE | Jonnu Smith TE | 1.80 | 100% |
| FLEX | Tee Higgins WR | 9.40 | 120.4% |
| FLEX | Jamaal Williams RB | 4.30 | |
| DST | Pittsburgh Steelers DST | 8.00 | 12.5% |
| Total | 103.68 | 82.4% | |