| Starters | ||
| Pos | Player | Points |
| QB | Brock Purdy QB | 29.84 |
| RB | Zach Charbonnet RB | 8.20 |
| RB | Keaton Mitchell RB | 13.10 |
| WR | Calvin Ridley WR | 3.00 |
| WR | Michael Pittman Jr. WR | 12.40 |
| WR | Jake Bobo WR | 2.30 |
| TE | Sam LaPorta TE | 6.00 |
| FLEX | David Njoku TE | 8.80 |
| FLEX | Trey McBride TE | 17.10 |
| DST | Buffalo Bills DST | 6.00 |
| Total | 106.74 | |
| Starters | ||
| Pos | Player | Points |
| QB | Jared Goff QB | 25.12 |
| RB | Samaje Perine RB | 5.80 |
| RB | Kenneth Walker RB | 19.20 |
| WR | Adam Thielen WR | 7.20 |
| WR | Rashid Shaheed WR | 8.70 |
| WR | Zay Flowers WR | 9.80 |
| TE | Cole Kmet TE | 7.10 |
| FLEX | Christian Kirk WR | 12.15 |
| FLEX | Deebo Samuel WR | 13.90 |
| DST | New England Patriots DST | 7.00 |
| Total | 115.97 | |
| Bench | ||
| Pos | Player | Points |
| BN | Detroit Lions DST | -4.00 |
| BN | Braxton Berrios WR | 0.00 |
| BN | Jeff Wilson Jr. RB | 0.00 |
| BN | Miles Sanders RB | 2.00 |
| BN | Jalen Hurts QB | 0.00 |
| BN | Nico Collins WR | 0.00 |
| BN | Kenneth Gainwell RB | 0.00 |
| BN | Justyn Ross WR | 0.00 |
| BN | Deuce Vaughn RB | 1.85 |
| BN | Emari Demercado RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Allen Robinson WR | 0.00 |
| BN | Nelson Agholor WR | 0.00 |
| BN | Tyler Higbee TE | 0.00 |
| BN | Josh Reynolds WR | 2.50 |
| BN | Kyler Murray QB | 15.26 |
| BN | Dameon Pierce RB | 0.00 |
| BN | Bryce Young QB | 9.20 |
| BN | Jalin Hyatt WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Brock Purdy QB | 29.84 | 100% |
| RB | Keaton Mitchell RB | 13.10 | 100% |
| RB | Zach Charbonnet RB | 8.20 | |
| WR | Michael Pittman Jr. WR | 12.40 | 83.1% |
| WR | Jordan Addison WR | 8.90 | |
| TE | Trey McBride TE | 17.10 | 35.1% |
| FLEX | David Njoku TE | 8.80 | 160.9% |
| FLEX | Jaxon Smith-Njigba WR | 7.30 | |
| DST | Buffalo Bills DST | 6.00 | 100% |
| Total | 111.64 | 95.6% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jared Goff QB | 25.12 | 100% |
| RB | Kenneth Walker RB | 19.20 | 100% |
| RB | Samaje Perine RB | 5.80 | |
| WR | Jayden Reed WR | 16.90 | 83.4% |
| WR | Deebo Samuel WR | 13.90 | |
| TE | Cole Kmet TE | 7.10 | 100% |
| FLEX | Christian Kirk WR | 12.15 | 118.7% |
| FLEX | Zay Flowers WR | 9.80 | |
| DST | New England Patriots DST | 7.00 | 100% |
| Total | 116.97 | 99.1% | |