| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 29.70 |
| RB | DAndre Swift RB | 18.20 |
| RB | Breece Hall RB | 15.80 |
| WR | Tyler Boyd WR | 3.70 |
| WR | Brandin Cooks WR | 5.70 |
| WR | Jerry Jeudy WR | 8.30 |
| TE | Tyler Conklin TE | 2.80 |
| FLEX | Dalvin Cook RB | 1.30 |
| FLEX | Rachaad White RB | 14.80 |
| DST | Los Angeles Rams DST | 7.00 |
| Total | 107.3 | |
| Starters | ||
| Pos | Player | Points |
| QB | Josh Allen QB | 26.50 |
| RB | Aaron Jones RB | 2.20 |
| RB | Christian McCaffrey RB | 18.80 |
| WR | Mike Evans WR | 12.80 |
| WR | Chris Godwin WR | 6.90 |
| WR | Gabriel Davis WR | 0.00 |
| TE | Dalton Schultz TE | 10.20 |
| FLEX | Raheem Mostert RB | 9.80 |
| FLEX | Alexander Mattison RB | 6.50 |
| DST | Washington Commanders DST | 11.00 |
| Total | 104.7 | |
| Bench | ||
| Pos | Player | Points |
| BN | Kenyan Drake RB | 0.00 |
| BN | New York Jets DST | 1.00 |
| BN | JuJu Smith-Schuster WR | 0.00 |
| BN | Matt Breida RB | -0.10 |
| BN | Kyle Pitts TE | 0.00 |
| BN | Desmond Ridder QB | 0.00 |
| BN | David Bell WR | 0.00 |
| BN | Isaiah Spiller RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | New York Giants DST | 19.00 |
| BN | Cincinnati Bengals DST | -1.00 |
| BN | Kansas City Chiefs DST | 9.00 |
| BN | Curtis Samuel WR | 1.00 |
| BN | Logan Thomas TE | 6.30 |
| BN | K.J. Osborn WR | 1.20 |
| BN | Antonio Gibson RB | 0.00 |
| BN | Calvin Austin WR | 2.55 |
| BN | Ty Chandler RB | 13.00 |
| BN | Michael Wilson WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 29.70 | 100% |
| RB | DAndre Swift RB | 18.20 | 100% |
| RB | Breece Hall RB | 15.80 | |
| WR | Jerry Jeudy WR | 8.30 | 126.4% |
| WR | Brandin Cooks WR | 5.70 | |
| TE | Tyler Conklin TE | 2.80 | 100% |
| FLEX | Rachaad White RB | 14.80 | 87% |
| FLEX | Tyler Boyd WR | 3.70 | |
| DST | Los Angeles Rams DST | 7.00 | 100% |
| Total | 106 | 101.2% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Josh Allen QB | 26.50 | 100% |
| RB | Christian McCaffrey RB | 18.80 | 66% |
| RB | Ty Chandler RB | 13.00 | |
| WR | Mike Evans WR | 12.80 | 100% |
| WR | Chris Godwin WR | 6.90 | |
| TE | Dalton Schultz TE | 10.20 | 100% |
| FLEX | Raheem Mostert RB | 9.80 | 100% |
| FLEX | Alexander Mattison RB | 6.50 | |
| DST | New York Giants DST | 19.00 | 57.9% |
| Total | 123.5 | 84.8% | |