| Starters | ||
| Pos | Player | Points |
| QB | Russell Wilson QB | 16.46 |
| RB | Derrick Henry RB | 4.90 |
| RB | Austin Ekeler RB | 6.00 |
| WR | DeAndre Hopkins WR | 13.90 |
| WR | Jakobi Meyers WR | 6.90 |
| WR | Amon-Ra St. Brown WR | 17.70 |
| TE | Cade Otton TE | 6.90 |
| FLEX | Tyreek Hill WR | 25.60 |
| FLEX | Brian Robinson RB | 16.60 |
| DST | Seattle Seahawks DST | 6.00 |
| Total | 120.96 | |
| Starters | ||
| Pos | Player | Points |
| QB | Justin Fields QB | 23.16 |
| RB | Jerick McKinnon RB | 2.50 |
| RB | Elijah Mitchell RB | 2.40 |
| WR | Tyler Lockett WR | 7.60 |
| WR | DJ Chark Jr. WR | 0.00 |
| WR | Trenton Irwin WR | 5.10 |
| TE | Pat Freiermuth TE | 1.20 |
| FLEX | Craig Reynolds RB | -0.45 |
| FLEX | DeVonta Smith WR | 12.90 |
| DST | Pittsburgh Steelers DST | 8.00 |
| Total | 62.41 | |
| Bench | ||
| Pos | Player | Points |
| BN | Tampa Bay Buccaneers DST | 1.00 |
| BN | Geno Smith QB | 15.22 |
| BN | Dallas Goedert TE | 0.00 |
| BN | Taysom Hill TE | 0.00 |
| BN | Brandon Powell WR | 6.05 |
| BN | Joshua Kelley RB | 1.30 |
| BN | Rico Dowdle RB | 3.00 |
| BN | Khalil Shakir WR | 19.00 |
| BN | Jonathan Mingo WR | 1.10 |
| BN | Kendre Miller RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Ezekiel Elliott RB | 0.00 |
| BN | Matthew Stafford QB | 9.70 |
| BN | San Francisco 49ers DST | 11.00 |
| BN | Leonard Fournette RB | 0.00 |
| BN | Jamaal Williams RB | 0.00 |
| BN | Jonnu Smith TE | 0.00 |
| BN | Noah Brown WR | 0.00 |
| BN | Baker Mayfield QB | 10.34 |
| BN | Jonathan Taylor RB | 0.00 |
| BN | Tee Higgins WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Russell Wilson QB | 16.46 | 100% |
| RB | Brian Robinson RB | 16.60 | 48.2% |
| RB | Austin Ekeler RB | 6.00 | |
| WR | Tyreek Hill WR | 25.60 | 86.3% |
| WR | Khalil Shakir WR | 19.00 | |
| TE | Cade Otton TE | 6.90 | 100% |
| FLEX | Amon-Ra St. Brown WR | 17.70 | 133.5% |
| FLEX | DeAndre Hopkins WR | 13.90 | |
| DST | Seattle Seahawks DST | 6.00 | 100% |
| Total | 128.16 | 94.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Fields QB | 23.16 | 100% |
| RB | Tyjae Spears RB | 7.65 | 48.3% |
| RB | Jerick McKinnon RB | 2.50 | |
| WR | DeVonta Smith WR | 12.90 | 62% |
| WR | Tyler Lockett WR | 7.60 | |
| TE | Luke Schoonmaker TE | 9.30 | 12.9% |
| FLEX | Trenton Irwin WR | 5.10 | 166% |
| FLEX | Elijah Mitchell RB | 2.40 | |
| DST | San Francisco 49ers DST | 11.00 | 72.7% |
| Total | 81.61 | 76.5% | |