| Starters | ||
| Pos | Player | Points |
| QB | C.J. Stroud QB | 34.86 |
| RB | Saquon Barkley RB | 5.70 |
| RB | Khalil Herbert RB | 4.80 |
| WR | Courtland Sutton WR | 7.60 |
| WR | Romeo Doubs WR | 5.20 |
| WR | Tank Dell WR | 14.70 |
| TE | George Kittle TE | 3.40 |
| FLEX | Keenan Allen WR | 15.60 |
| FLEX | A.J. Brown WR | 12.20 |
| DST | Baltimore Ravens DST | 16.00 |
| Total | 120.06 | |
| Starters | ||
| Pos | Player | Points |
| QB | Russell Wilson QB | 18.76 |
| RB | Derrick Henry RB | 20.10 |
| RB | Brian Robinson RB | 7.40 |
| WR | DeAndre Hopkins WR | 6.40 |
| WR | Tyreek Hill WR | 20.90 |
| WR | Amon-Ra St. Brown WR | 14.00 |
| TE | Taysom Hill TE | 7.10 |
| FLEX | Austin Ekeler RB | 6.90 |
| FLEX | Khalil Shakir WR | 8.05 |
| DST | Tampa Bay Buccaneers DST | 3.00 |
| Total | 112.61 | |
| Bench | ||
| Pos | Player | Points |
| BN | Los Angeles Chargers DST | 1.00 |
| BN | Joshua Dobbs QB | -1.50 |
| BN | Kareem Hunt RB | 2.20 |
| BN | Irv Smith Jr. TE | 1.80 |
| BN | Jordan Love QB | 32.62 |
| BN | Rashod Bateman WR | 3.10 |
| BN | Tutu Atwell WR | 9.10 |
| BN | George Pickens WR | 7.65 |
| BN | Tyler Allgeier RB | 6.40 |
| BN | Will Levis QB | 7.10 |
| Bench | ||
| Pos | Player | Points |
| BN | Seattle Seahawks DST | 7.00 |
| BN | Geno Smith QB | 5.30 |
| BN | Dallas Goedert TE | 0.00 |
| BN | Brandon Powell WR | 6.95 |
| BN | Jakobi Meyers WR | 17.10 |
| BN | Joshua Kelley RB | 2.40 |
| BN | Rico Dowdle RB | 9.10 |
| BN | Cade Otton TE | 6.50 |
| BN | Jonathan Mingo WR | 8.00 |
| BN | Kendre Miller RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | C.J. Stroud QB | 34.86 | 100% |
| RB | Tyler Allgeier RB | 6.40 | 86.8% |
| RB | Saquon Barkley RB | 5.70 | |
| WR | Keenan Allen WR | 15.60 | 90.8% |
| WR | Tank Dell WR | 14.70 | |
| TE | George Kittle TE | 3.40 | 100% |
| FLEX | A.J. Brown WR | 12.20 | 130.5% |
| FLEX | Tutu Atwell WR | 9.10 | |
| DST | Baltimore Ravens DST | 16.00 | 100% |
| Total | 117.96 | 101.8% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Russell Wilson QB | 18.76 | 100% |
| RB | Derrick Henry RB | 20.10 | 94.2% |
| RB | Rico Dowdle RB | 9.10 | |
| WR | Tyreek Hill WR | 20.90 | 108.7% |
| WR | Jakobi Meyers WR | 17.10 | |
| TE | Taysom Hill TE | 7.10 | 100% |
| FLEX | Amon-Ra St. Brown WR | 14.00 | 67.8% |
| FLEX | Khalil Shakir WR | 8.05 | |
| DST | Seattle Seahawks DST | 7.00 | 42.9% |
| Total | 122.11 | 92.2% | |