| Starters | ||
| Pos | Player | Points |
| QB | Justin Herbert QB | 13.38 |
| RB | DAndre Swift RB | 8.90 |
| RB | Breece Hall RB | 8.40 |
| WR | Tyler Boyd WR | 3.80 |
| WR | Brandin Cooks WR | 15.20 |
| WR | Jerry Jeudy WR | 2.10 |
| TE | Kyle Pitts TE | 3.20 |
| FLEX | Tyler Conklin TE | 5.30 |
| FLEX | Rachaad White RB | 12.00 |
| DST | Los Angeles Rams DST | 7.00 |
| Total | 79.28 | |
| Starters | ||
| Pos | Player | Points |
| QB | Jalen Hurts QB | 38.50 |
| RB | Zach Charbonnet RB | 7.80 |
| RB | Keaton Mitchell RB | 9.90 |
| WR | Calvin Ridley WR | 19.40 |
| WR | Michael Pittman Jr. WR | 15.70 |
| WR | Nico Collins WR | 19.90 |
| TE | Sam LaPorta TE | 15.20 |
| FLEX | David Njoku TE | 8.90 |
| FLEX | Trey McBride TE | 9.50 |
| DST | Detroit Lions DST | -1.00 |
| Total | 143.8 | |
| Bench | ||
| Pos | Player | Points |
| BN | Kenyan Drake RB | 0.00 |
| BN | New York Jets DST | 12.00 |
| BN | Dalvin Cook RB | 3.10 |
| BN | JuJu Smith-Schuster WR | 2.00 |
| BN | Matt Breida RB | 2.10 |
| BN | Desmond Ridder QB | 7.72 |
| BN | David Bell WR | 0.00 |
| BN | Isaiah Spiller RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Buffalo Bills DST | 2.00 |
| BN | Braxton Berrios WR | 3.40 |
| BN | Jeff Wilson Jr. RB | 8.80 |
| BN | Miles Sanders RB | 2.80 |
| BN | Kenneth Gainwell RB | 4.60 |
| BN | Brock Purdy QB | 10.46 |
| BN | Justyn Ross WR | 0.00 |
| BN | Deuce Vaughn RB | 0.00 |
| BN | Emari Demercado RB | 1.50 |
| BN | Jake Bobo WR | 1.10 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Justin Herbert QB | 13.38 | 100% |
| RB | Rachaad White RB | 12.00 | 82.8% |
| RB | DAndre Swift RB | 8.90 | |
| WR | Brandin Cooks WR | 15.20 | 111.1% |
| WR | Tyler Boyd WR | 3.80 | |
| TE | Tyler Conklin TE | 5.30 | 60.4% |
| FLEX | Breece Hall RB | 8.40 | 149.1% |
| FLEX | Kyle Pitts TE | 3.20 | |
| DST | New York Jets DST | 12.00 | 58.3% |
| Total | 82.18 | 96.5% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jalen Hurts QB | 38.50 | 100% |
| RB | Keaton Mitchell RB | 9.90 | 94.7% |
| RB | Jeff Wilson Jr. RB | 8.80 | |
| WR | Nico Collins WR | 19.90 | 139.9% |
| WR | Calvin Ridley WR | 19.40 | |
| TE | Sam LaPorta TE | 15.20 | 100% |
| FLEX | Michael Pittman Jr. WR | 15.70 | 73% |
| FLEX | Trey McBride TE | 9.50 | |
| DST | Buffalo Bills DST | 2.00 | -50% |
| Total | 138.9 | 103.5% | |