| Starters | ||
| Pos | Player | Points |
| QB | Russell Wilson QB | 11.84 |
| RB | Derrick Henry RB | 24.50 |
| RB | Brian Robinson RB | 5.30 |
| WR | DeAndre Hopkins WR | 16.40 |
| WR | Tyreek Hill WR | 29.80 |
| WR | Amon-Ra St. Brown WR | 11.90 |
| TE | Taysom Hill TE | 14.40 |
| FLEX | Austin Ekeler RB | 3.70 |
| FLEX | Jonathan Mingo WR | 9.90 |
| DST | Tampa Bay Buccaneers DST | 8.00 |
| Total | 135.74 | |
| Starters | ||
| Pos | Player | Points |
| QB | Kyler Murray QB | 13.80 |
| RB | Samaje Perine RB | 1.60 |
| RB | Dameon Pierce RB | 10.10 |
| WR | Allen Robinson WR | 3.40 |
| WR | Josh Reynolds WR | 1.70 |
| WR | Adam Thielen WR | 4.00 |
| TE | Tyler Higbee TE | 4.50 |
| FLEX | Christian Kirk WR | 3.10 |
| FLEX | Deebo Samuel WR | 36.80 |
| DST | Houston Texans DST | 12.00 |
| Total | 91 | |
| Bench | ||
| Pos | Player | Points |
| BN | Seattle Seahawks DST | -2.00 |
| BN | Geno Smith QB | 33.96 |
| BN | Dallas Goedert TE | 0.00 |
| BN | Brandon Powell WR | 0.00 |
| BN | Jakobi Meyers WR | 0.00 |
| BN | Joshua Kelley RB | 3.50 |
| BN | Rico Dowdle RB | 2.70 |
| BN | Cade Otton TE | 0.00 |
| BN | Khalil Shakir WR | 0.00 |
| BN | Kendre Miller RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Nelson Agholor WR | 0.00 |
| BN | New England Patriots DST | 6.00 |
| BN | Jared Goff QB | 20.32 |
| BN | DOnta Foreman RB | 0.00 |
| BN | Cole Kmet TE | 0.00 |
| BN | Kenneth Walker RB | 0.00 |
| BN | Rashid Shaheed WR | 0.00 |
| BN | Zay Flowers WR | 0.00 |
| BN | Bryce Young QB | 5.12 |
| BN | Jalin Hyatt WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Geno Smith QB | 33.96 | 34.9% |
| RB | Derrick Henry RB | 24.50 | 100% |
| RB | Brian Robinson RB | 5.30 | |
| WR | Tyreek Hill WR | 29.80 | 125.8% |
| WR | DeAndre Hopkins WR | 16.40 | |
| TE | Taysom Hill TE | 14.40 | 100% |
| FLEX | Amon-Ra St. Brown WR | 11.90 | 62.4% |
| FLEX | Jonathan Mingo WR | 9.90 | |
| DST | Tampa Bay Buccaneers DST | 8.00 | 100% |
| Total | 154.16 | 88.1% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jared Goff QB | 20.32 | 67.9% |
| RB | Dameon Pierce RB | 10.10 | 100% |
| RB | Samaje Perine RB | 1.60 | |
| WR | Deebo Samuel WR | 36.80 | 20.1% |
| WR | DeVante Parker WR | 8.40 | |
| TE | Tyler Higbee TE | 4.50 | 100% |
| FLEX | Adam Thielen WR | 4.00 | 525% |
| FLEX | Jayden Reed WR | 3.60 | |
| DST | Houston Texans DST | 12.00 | 100% |
| Total | 101.32 | 89.8% | |