| Starters | ||
| Pos | Player | Points |
| QB | Kirk Cousins QB | 11.90 |
| RB | Marshawn Lynch RB | 11.40 |
| RB | Bilal Powell RB | 1.30 |
| WR | Julio Jones WR | 13.30 |
| WR | Golden Tate WR | 4.50 |
| TE | Jimmy Graham TE | 0.60 |
| FLEX | Ty Montgomery RB | 26.00 |
| FLEX | Jarvis Landry WR | 13.60 |
| DST | Kansas City Chiefs DST | 7.00 |
| Total | 89.6 | |
| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 22.20 |
| RB | Mark Ingram RB | 9.60 |
| RB | LeSean McCoy RB | 7.30 |
| WR | Antonio Brown WR | 8.70 |
| WR | Jordy Nelson WR | 0.00 |
| TE | Delanie Walker TE | 14.20 |
| FLEX | Michael Crabtree WR | 29.00 |
| FLEX | Martavis Bryant WR | 17.30 |
| DST | Los Angeles Chargers DST | 2.00 |
| Total | 110.3 | |
| Bench | ||
| Pos | Player | Points |
| BN | Samaje Perine RB | 7.20 |
| BN | Frank Gore RB | 10.60 |
| BN | LeGarrette Blount RB | 0.50 |
| BN | Brandon Marshall WR | 2.20 |
| BN | Breshad Perriman WR | 0.00 |
| BN | Taylor Gabriel WR | 3.10 |
| BN | DeSean Jackson WR | 5.40 |
| BN | Kenny Britt WR | 0.70 |
| BN | Mike Wallace WR | 1.20 |
| BN | Alex Smith QB | 16.10 |
| Bench | ||
| Pos | Player | Points |
| BN | Eli Manning QB | 11.60 |
| BN | Joe Mixon RB | 4.60 |
| BN | Wendell Smallwood RB | 3.40 |
| BN | Cole Beasley WR | 5.30 |
| BN | Robby Anderson WR | 3.80 |
| BN | James Conner RB | 0.90 |
| BN | Chris Carson RB | 10.50 |
| BN | Deshaun Watson QB | 17.70 |
| BN | Terrance Williams WR | 3.70 |
| BN | Coby Fleener TE | 10.80 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Alex Smith QB | 16.10 | 73.9% |
| RB | Ty Montgomery RB | 26.00 | 34% |
| RB | Marshawn Lynch RB | 11.40 | |
| WR | Jarvis Landry WR | 13.60 | 66.2% |
| WR | Julio Jones WR | 13.30 | |
| TE | Jimmy Graham TE | 0.60 | 100% |
| FLEX | Frank Gore RB | 10.60 | 222.5% |
| FLEX | Samaje Perine RB | 7.20 | |
| DST | Kansas City Chiefs DST | 7.00 | 100% |
| Total | 105.8 | 84.7% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Brees QB | 22.20 | 100% |
| RB | Chris Carson RB | 10.50 | 84.1% |
| RB | Mark Ingram RB | 9.60 | |
| WR | Michael Crabtree WR | 29.00 | 18.8% |
| WR | Martavis Bryant WR | 17.30 | |
| TE | Delanie Walker TE | 14.20 | 100% |
| FLEX | Coby Fleener TE | 10.80 | 237.4% |
| FLEX | Antonio Brown WR | 8.70 | |
| DST | Los Angeles Chargers DST | 2.00 | 100% |
| Total | 124.3 | 88.7% | |