| Starters | ||
| Pos | Player | Points |
| QB | Marcus Mariota QB | 7.80 |
| RB | Latavius Murray RB | 14.40 |
| RB | Jerick McKinnon RB | 5.90 |
| WR | Randall Cobb WR | 13.80 |
| WR | Terrance Williams WR | 8.00 |
| TE | Evan Engram TE | 3.30 |
| FLEX | Dion Lewis RB | 13.60 |
| FLEX | Tyrell Williams WR | 12.80 |
| DST | Pittsburgh Steelers DST | 3.00 |
| Total | 82.6 | |
| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 28.90 |
| RB | Carlos Hyde RB | 10.30 |
| RB | Jordan Howard RB | 2.90 |
| WR | Jordan Matthews WR | 2.50 |
| WR | Tyler Lockett WR | 1.90 |
| TE | Travis Kelce TE | 5.40 |
| FLEX | Derrick Henry RB | 9.40 |
| FLEX | Devontae Booker RB | 5.00 |
| DST | Philadelphia Eagles DST | 13.00 |
| Total | 79.3 | |
| Bench | ||
| Pos | Player | Points |
| BN | Kelvin Benjamin WR | 0.00 |
| BN | Chris Hogan WR | 0.00 |
| BN | Pierre Garcon WR | 0.00 |
| BN | Arizona Cardinals DST | 11.00 |
| BN | Charcandrick West RB | 4.10 |
| BN | Kerwynn Williams RB | 3.40 |
| BN | Ed Dickson TE | 2.00 |
| BN | Josh McCown QB | 25.10 |
| BN | Eddie Lacy RB | 7.60 |
| BN | Greg Olsen TE | 1.50 |
| Bench | ||
| Pos | Player | Points |
| BN | David Johnson RB | 0.00 |
| BN | Terrance West RB | 0.00 |
| BN | Theo Riddick RB | 3.50 |
| BN | Odell Beckham WR | 0.00 |
| BN | Donte Moncrief WR | 2.10 |
| BN | Willie Snead WR | 1.40 |
| BN | Cameron Brate TE | 1.10 |
| BN | Los Angeles Rams DST | 3.00 |
| BN | Jay Cutler QB | 0.00 |
| BN | Ben Roethlisberger QB | 30.50 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Josh McCown QB | 25.10 | 31.1% |
| RB | Latavius Murray RB | 14.40 | 72.5% |
| RB | Dion Lewis RB | 13.60 | |
| WR | Randall Cobb WR | 13.80 | 82% |
| WR | Tyrell Williams WR | 12.80 | |
| TE | Evan Engram TE | 3.30 | 100% |
| FLEX | Terrance Williams WR | 8.00 | 169.2% |
| FLEX | Eddie Lacy RB | 7.60 | |
| DST | Arizona Cardinals DST | 11.00 | 27.3% |
| Total | 109.6 | 75.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Ben Roethlisberger QB | 30.50 | 94.8% |
| RB | Carlos Hyde RB | 10.30 | 67% |
| RB | Derrick Henry RB | 9.40 | |
| WR | Donte Moncrief WR | 2.10 | 110% |
| WR | Tyler Lockett WR | 1.90 | |
| TE | Travis Kelce TE | 5.40 | 100% |
| FLEX | Devontae Booker RB | 5.00 | 169.4% |
| FLEX | Theo Riddick RB | 3.50 | |
| DST | Philadelphia Eagles DST | 13.00 | 100% |
| Total | 81.1 | 97.8% | |