| Starters | ||
| Pos | Player | Points |
| QB | C.J. Stroud QB | 3.64 |
| RB | Kareem Hunt RB | 9.50 |
| RB | Saquon Barkley RB | 21.60 |
| WR | Keenan Allen WR | 9.80 |
| WR | Courtland Sutton WR | 13.70 |
| WR | George Pickens WR | 4.40 |
| TE | George Kittle TE | 15.10 |
| FLEX | A.J. Brown WR | 11.90 |
| FLEX | Romeo Doubs WR | 5.20 |
| DST | Baltimore Ravens DST | 4.00 |
| Total | 98.84 | |
| Starters | ||
| Pos | Player | Points |
| QB | Josh Allen QB | 20.52 |
| RB | Christian McCaffrey RB | 15.80 |
| RB | Raheem Mostert RB | 22.50 |
| WR | Mike Evans WR | 1.30 |
| WR | Chris Godwin WR | 7.80 |
| WR | Gabriel Davis WR | 0.00 |
| TE | Tucker Kraft TE | 8.40 |
| FLEX | Alexander Mattison RB | 6.60 |
| FLEX | Dontayvion Wicks WR | 3.00 |
| DST | Cincinnati Bengals DST | 12.00 |
| Total | 97.92 | |
| Bench | ||
| Pos | Player | Points |
| BN | Los Angeles Chargers DST | 4.00 |
| BN | Joshua Dobbs QB | 4.62 |
| BN | Irv Smith Jr. TE | 0.00 |
| BN | Jordan Love QB | 8.92 |
| BN | Rashod Bateman WR | 3.40 |
| BN | Tutu Atwell WR | 0.00 |
| BN | Khalil Herbert RB | 0.80 |
| BN | Tyler Allgeier RB | 4.00 |
| BN | Will Levis QB | 16.58 |
| BN | Tank Dell WR | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Kansas City Chiefs DST | 5.00 |
| BN | Aaron Jones RB | 0.00 |
| BN | Curtis Samuel WR | 0.00 |
| BN | Logan Thomas TE | 0.00 |
| BN | Dalton Schultz TE | 0.00 |
| BN | Allen Lazard WR | 0.00 |
| BN | Jake Browning QB | 25.70 |
| BN | Antonio Gibson RB | 0.00 |
| BN | Ty Chandler RB | 5.70 |
| BN | Michael Wilson WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Will Levis QB | 16.58 | 22% |
| RB | Saquon Barkley RB | 21.60 | 100% |
| RB | Kareem Hunt RB | 9.50 | |
| WR | Courtland Sutton WR | 13.70 | 109% |
| WR | A.J. Brown WR | 11.90 | |
| TE | George Kittle TE | 15.10 | 100% |
| FLEX | Quentin Johnston WR | 10.60 | 83.8% |
| FLEX | Keenan Allen WR | 9.80 | |
| DST | Los Angeles Chargers DST | 4.00 | 100% |
| Total | 112.78 | 87.6% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jake Browning QB | 25.70 | 79.8% |
| RB | Raheem Mostert RB | 22.50 | 100% |
| RB | Christian McCaffrey RB | 15.80 | |
| WR | Chris Godwin WR | 7.80 | 84.3% |
| WR | Dontayvion Wicks WR | 3.00 | |
| TE | Tucker Kraft TE | 8.40 | 100% |
| FLEX | Alexander Mattison RB | 6.60 | 78% |
| FLEX | Ty Chandler RB | 5.70 | |
| DST | Cincinnati Bengals DST | 12.00 | 100% |
| Total | 107.5 | 91.1% | |