| Starters | ||
| Pos | Player | Points |
| QB | Russell Wilson QB | 19.52 |
| RB | Derrick Henry RB | 3.00 |
| RB | Austin Ekeler RB | 5.80 |
| WR | DeAndre Hopkins WR | 3.10 |
| WR | Amon-Ra St. Brown WR | 20.70 |
| WR | Jonathan Mingo WR | 5.20 |
| TE | Dallas Goedert TE | 5.10 |
| FLEX | Taysom Hill TE | 1.90 |
| FLEX | Jakobi Meyers WR | 16.68 |
| DST | Tampa Bay Buccaneers DST | 4.00 |
| Total | 85 | |
| Starters | ||
| Pos | Player | Points |
| QB | Justin Fields QB | 7.64 |
| RB | Ezekiel Elliott RB | 7.10 |
| RB | Jerick McKinnon RB | 16.66 |
| WR | Tyler Lockett WR | 3.60 |
| WR | Tee Higgins WR | 20.10 |
| WR | DeVonta Smith WR | 7.50 |
| TE | Pat Freiermuth TE | 3.10 |
| FLEX | Jamaal Williams RB | 3.10 |
| FLEX | Noah Brown WR | 18.20 |
| DST | San Francisco 49ers DST | 9.00 |
| Total | 96 | |
| Bench | ||
| Pos | Player | Points |
| BN | Seattle Seahawks DST | 5.00 |
| BN | Tyreek Hill WR | 0.00 |
| BN | Geno Smith QB | 0.00 |
| BN | Brandon Powell WR | 1.10 |
| BN | Joshua Kelley RB | 1.30 |
| BN | Rico Dowdle RB | 2.20 |
| BN | Brian Robinson RB | 0.00 |
| BN | Cade Otton TE | 5.40 |
| BN | Khalil Shakir WR | 0.00 |
| BN | Kendre Miller RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Pittsburgh Steelers DST | 3.00 |
| BN | Matthew Stafford QB | 22.52 |
| BN | Leonard Fournette RB | 0.00 |
| BN | Jonnu Smith TE | 7.10 |
| BN | Baker Mayfield QB | 37.04 |
| BN | DJ Chark Jr. WR | 2.30 |
| BN | Craig Reynolds RB | 1.30 |
| BN | Trenton Irwin WR | 0.00 |
| BN | Jonathan Taylor RB | 0.00 |
| BN | Elijah Mitchell RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Russell Wilson QB | 19.52 | 100% |
| RB | Austin Ekeler RB | 5.80 | 100% |
| RB | Derrick Henry RB | 3.00 | |
| WR | Amon-Ra St. Brown WR | 20.70 | 77.6% |
| WR | Jakobi Meyers WR | 16.68 | |
| TE | Cade Otton TE | 5.40 | 94.4% |
| FLEX | Jonathan Mingo WR | 5.20 | 180.4% |
| FLEX | Dallas Goedert TE | 5.10 | |
| DST | Seattle Seahawks DST | 5.00 | 80% |
| Total | 86.4 | 98.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Baker Mayfield QB | 37.04 | 20.6% |
| RB | Jerick McKinnon RB | 16.66 | 100% |
| RB | Ezekiel Elliott RB | 7.10 | |
| WR | Tee Higgins WR | 20.10 | 81.5% |
| WR | Noah Brown WR | 18.20 | |
| TE | Jonnu Smith TE | 7.10 | 43.7% |
| FLEX | Justin Jefferson WR | 11.90 | 109.8% |
| FLEX | DeVonta Smith WR | 7.50 | |
| DST | San Francisco 49ers DST | 9.00 | 100% |
| Total | 134.6 | 71.3% | |